CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)

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Accession:125152
A model of a CA1 pyramidal neuron containing a biophysically realistic morphology and 15 distributed voltage and Ca2+-dependent conductances. Repetitive firing is modulated by maximal conductance and the voltage dependence of the persistent Na+ current (INaP).
Reference:
1 . Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci 30:8489-501 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Epilepsy;
Implementer(s): Horstmann, Marie-Therese [mhorstma at uni-bonn.de];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX ca2dyn
	USEION ca READ ica
	USEION ca2 READ ca2i WRITE ca2i VALENCE 2.0
	RANGE depth,ca2inf,taur
}

UNITS {
	(molar) = (1/liter)			: moles do not appear in units
	(mM)	= (millimolar)
	(um)	= (micron)
	(mA)	= (milliamp)
	(msM)	= (ms mM)
}

CONSTANT {
	FARADAY = 96489		(coul)		: moles do not appear in units
}

PARAMETER {
	depth	= 1	(um)		: depth of shell
	taur	= 1000	(ms)		
	ca2inf	= 1e-4 (mM)
}

STATE {
	ca2i		(mM) 
}

INITIAL {
	ca2i = ca2inf
}

ASSIGNED {
	ica		(mA/cm2)
	drive_channel	(mM/ms)
}
	
BREAKPOINT {
	SOLVE state METHOD cnexp
}

DERIVATIVE state { 

	drive_channel =  - (10000)  * ica / (83.3333 * FARADAY * depth)

	ca2i' = drive_channel + (ca2inf-ca2i)/taur
}