CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)

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Accession:125152
A model of a CA1 pyramidal neuron containing a biophysically realistic morphology and 15 distributed voltage and Ca2+-dependent conductances. Repetitive firing is modulated by maximal conductance and the voltage dependence of the persistent Na+ current (INaP).
Reference:
1 . Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci 30:8489-501 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Epilepsy;
Implementer(s): Horstmann, Marie-Therese [mhorstma at uni-bonn.de];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,p; I Na,t; I p,q; I A; I K,leak; I M; I K,Ca; I CAN; I Calcium; ATP-senstive potassium current;
:potassium leakage current

NEURON {
  SUFFIX kleck
  USEION k READ ek WRITE ik
  RANGE gbar, g, i
}

UNITS {
  (S) = (siemens)
  (mV) = (millivolt)
  (mA) = (milliamp)	
}

PARAMETER {
  gbar = 0.001 (S/cm2) :aus dem Paper abgeschrieben
  eK = -95 (mV)	
}

ASSIGNED {
  v	(mV)
  ek	(mV)
  ik 	(mA/cm2)
  i 	(mA/cm2)
  g	(S/cm2)
  
}

BREAKPOINT {
  i = gbar*(v-eK)
  ik = i
}