"... we measured T-type current of isolated
goldfish retinal ganglion cells with perforated-patch voltageclamp
methods in solutions containing a normal extracellular Ca2+
concentration.
The voltage sensitivities and rates of current activation,
inactivation, deactivation, and recovery from inactivation were similar
to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that
the rate of deactivation was significantly faster.
We reproduced the
amplitude and kinetics of measured T currents with a numerical
simulation based on a kinetic model developed for an +1G Ca2+
channel.
Finally, we show that this model predicts the increase of
T-type current made available between resting potential and spike
threshold by repetitive hyperpolarizations presented at rates that are
within the bandwidth of signals processed in situ by these neurons."
Reference:
1 .
Lee SC, Hayashida Y, Ishida AT (2003) Availability of low-threshold Ca2+ current in retinal ganglion cells. J Neurophysiol 90:3888-901 [PubMed]
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