Hippocampus CA1: Temporal sensitivity of signaling pathways underlying LTP (Kim et al. 2010)

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Accession:125733
Temporal sensitivity of signaling pathways underlying L-LTP. Single compartment, deterministic model of calcium and dopamine activated pathways, leading to CaMKII and PKA activation. Experimental verification of model prediction.
Reference:
1 . Kim M, Huang T, Abel T, Blackwell KT (2010) Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS Comput Biol 6:e1000691 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): Dopaminergic Receptor;
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: XPP;
Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Dopaminergic Receptor; Dopamine;