"The objective of this current study was to investigate whether voltage gated Ca(2+) channels are present
on axons of the adult rat optic nerve (RON).
Simulations of axonal excitability using a Hodgkin-Huxley based
one-compartment model incorporating I(Na), I(K) and leak currents were used to predict conditions under
which the potential contribution of a Ca(2+) current to an evoked action potential could be measured.
... , as predicted by the simulation, reducing the repolarizing effect of I(K) by adding the
K(+) channel blocker 4-AP revealed a Ca(2+) component on the repolarizing phase of the action potential that
was blocked by the Ca(2+) channel inhibitor nifedipine."
Brown AM (2003) A modeling study predicts the presence of voltage gated Ca2+ channels on myelinated central axons. Comput Methods Programs Biomed 71:25-31 [PubMed]
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