Olfactory bulb cluster formation (Migliore et al. 2010)

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Accession:127995
Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb.
Reference:
1 . Migliore M, Hines ML, McTavish TS, Shepherd GM (2010) Functional roles of distributed synaptic clusters in the mitral-granule cell network of the olfactory bulb. Front Integr Neurosci 4:122 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Short-term Synaptic Plasticity; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu]; Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; AMPA; I Na,t; I K;
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migliore2010
README
ampanmda.mod
fi.mod
kamt.mod *
kdrmt.mod *
naxn.mod *
ThreshDetect.mod *
.hg_archival.txt
6.2.3.2203.spk
allsynhinton.hoc *
clear.hoc *
connect.hoc
granule.hoc
iterator.hoc
lptiter.hoc
mgrs.hoc
mitral.hoc
mosinit.hoc
net-5mt-100-900.hoc
odors.txt
parinit.hoc
pattern.hoc
perfrun.hoc
show.hoc
somesyn.hoc *
start.hoc
start.ses *
stim-odors-AB-seq.hoc
weight_movie.hoc *
weight-forfig3-bulb1.dat
weightsave.hoc
                            
proc connect_cells() {local i, j
	for i=0, nmitral-1 {
		for j=0, ngranule-1 {
			mgconnect(i, j)
		}
	}
}

// connect mitral $1 to granule $2 based on mitral position and granule
// position. Only connect if secden long enough to reach granule
proc mgconnect() {local mp, gp, delta, x  localobj mgrs
	mp = mitral_x.x[$1]
	gp = len*($2+.5)/ngranule
	delta = gp - mp
	if (abs(delta) > Lsec) { return }
	x = delta/Lsec
	if (delta >= 0) { // use secden[0]
		mgrs = mk_mgrs($1, "secden[0]", x, $2, "dend[0]", 1)
	}else{ // use secden[1]
		mgrs = mk_mgrs($1, "secden[1]", -x, $2, "dend[0]", 1)
	}
	// store position and relation info in synapse to aid in
	// selection and movie making
	if (object_id(mgrs)) {
		if (mgrs.mexist) {
			mgrs.fi.mgid = mgrs.mitral_gid
			mgrs.fi.ggid = mgrs.granule_gid
			mgrs.fi.srcgid = mgrs.gd_gid
			mgrs.fi.x = gp
		}
		if (mgrs.gexist) {
			mgrs.ampanmda.mgid = mgrs.mitral_gid
			mgrs.ampanmda.ggid = mgrs.granule_gid
			mgrs.ampanmda.srcgid = mgrs.md_gid
			mgrs.ampanmda.x = gp
		}
	}
}