Short term plasticity at the cerebellar granule cell (Nieus et al. 2006)

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Accession:128446
The model reproduces short term plasticity of the mossy fibre to granule cell synapse. To reproduce synaptic currents recorded in experiments, a model of presynaptic release was used to determine the concentration of glutamate in the synaptic cleft that ultimately determined a synaptic response. The parameters of facilitation and depression were determined deconvolving AMPA EPSCs.
Reference:
1 . Nieus T, Sola E, Mapelli J, Saftenku E, Rossi P, D'Angelo E (2006) LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions. J Neurophysiol 95:686-99 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity;
Implementer(s): Nieus, Thierry [thierry.nieus at iit.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; AMPA; NMDA; Glutamate;
// DEMO SOFTWARE FOR THE PAPER NIEUS et al. 2006 
// For any questions email me: thierry.nieus AT iit.it
// Simulates figure 7 of the former paper

xopen("$(NEURONHOME)/lib/hoc/noload.hoc") 

create soma
access soma 

objref stimfib,conMFnmda,conMFampa
objref synA,synN

stimfib=new SpikeGenerator2(0.5)
synA=new Ampa(0.5)
synN=new Nmda(0.5)
conMFampa=new NetCon(stimfib, synA,-20, 0.000, 1e-3)
conMFnmda=new NetCon(stimfib, synN,-20, 0.000, 1e-3)

stimfib.start=50

for j=1,9 {stimfib.time[j]=10}
stimfib.time[j]=1e5

load_proc("nrnmainmenu") 
load_file("init.ses")

nrnmainmenu() 
tstop=250
Prel=0.416

proc MenuReleaseProbability(){
	xpanel("")
	xlabel("Mossy fibre to Granule Cell Release Probability")
	xvalue("MF to GRC synapse Prel","Prel",1,"synA.U=synN.U=Prel")
	xpanel()
}