Advanced search
User account
Login
Register
Find models by
Model name
First author
Each author
Find models for
Brain region
Concept
Find models of
Realistic Microcircuits
Connectionist Networks
High frequency oscillations in a hippocampal computational model (Stacey et al. 2009)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Accession:
135902
"... Using a physiological computer model of hippocampus, we investigate random synaptic activity (noise) as a potential initiator of HFOs (high-frequency oscillations). We explore parameters necessary to produce these oscillations and quantify the response using the tools of stochastic resonance (SR) and coherence resonance (CR). ... Our results show that, under normal coupling conditions, synaptic noise was able to produce gamma (30–100 Hz) frequency oscillations. Synaptic noise generated HFOs in the ripple range (100–200 Hz) when the network had parameters similar to pathological findings in epilepsy: increased gap junctions or recurrent synaptic connections, loss of inhibitory interneurons such as basket cells, and increased synaptic noise. ... We propose that increased synaptic noise and physiological coupling mechanisms are sufficient to generate gamma oscillations and that pathologic changes in noise and coupling similar to those in epilepsy can produce abnormal ripples."
Reference:
1 .
Stacey WC, Lazarewicz MT, Litt B (2009) Synaptic noise and physiological coupling generate high-frequency oscillations in a hippocampal computational model.
J Neurophysiol
102
:2342-57
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Hippocampus CA3 pyramidal GLU cell;
Hippocampus CA1 interneuron oriens alveus GABA cell;
Hippocampus CA1 basket cell;
Channel(s):
I Na,t;
I A;
I K;
I h;
Gap Junctions:
Gap junctions;
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Oscillations;
Implementer(s):
Lazarewicz, Maciej [mlazarew at gmu.edu];
Stacey, William [wstacey at med.umich.edu];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
Hippocampus CA3 pyramidal GLU cell
;
Hippocampus CA1 interneuron oriens alveus GABA cell
;
GabaA
;
AMPA
;
NMDA
;
I Na,t
;
I A
;
I K
;
I h
;
/
SRandCRnet
mod
CA1ih.mod
*
Other models using CA1ih.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
CA1ika.mod
*
Other models using CA1ika.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
CA1ikdr.mod
*
Other models using CA1ikdr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
CA1ina.mod
*
Other models using CA1ina.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
caolmw.mod
*
Other models using caolmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
capr.mod
*
Other models using capr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Edrive.mod
*
Other models using Edrive.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Exp2SynAMPA.mod
*
Other models using Exp2SynAMPA.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Exp2SynAMPApre.mod
*
Other models using Exp2SynAMPApre.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Exp2SynNMDA.mod
*
Other models using Exp2SynNMDA.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Exp2SynNMDAperm.mod
*
Other models using Exp2SynNMDAperm.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
Exp2SynNMDApre.mod
*
Other models using Exp2SynNMDApre.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
fvpre.mod
*
Other models using fvpre.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
gap.mod
*
Other models using gap.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
halfgap.mod
*
Other models using halfgap.mod:
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
icaolmw.mod
*
Other models using icaolmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
icapr.mod
*
Other models using icapr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
iholmkop.mod
*
Other models using iholmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
iholmw.mod
*
Other models using iholmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
ihpyrkop.mod
*
Other models using ihpyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kahppr.mod
*
Other models using kahppr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kaolmkop.mod
*
Other models using kaolmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kapyrkop.mod
*
Other models using kapyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kcaolmw.mod
*
Other models using kcaolmw.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kcpr.mod
*
Other models using kcpr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrbwb.mod
*
Other models using kdrbwb.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrca1.mod
*
Other models using kdrca1.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrolmkop.mod
*
Other models using kdrolmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrpr.mod
*
Other models using kdrpr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
kdrpyrkop.mod
*
Other models using kdrpyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
na3n.mod
*
Other models using na3n.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafbwb.mod
*
Other models using nafbwb.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafolmkop.mod
*
Other models using nafolmkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafpr.mod
*
Other models using nafpr.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
nafpyrkop.mod
*
Other models using nafpyrkop.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
par_ggap.mod
*
Other models using par_ggap.mod:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
aux_fun.inc
*
Other models using aux_fun.inc:
Computational analysis of NN activity and spatial reach of sharp wave-ripples (Canakci et al 2017)
Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)
Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
File not selected
<- Select file from this column.
