Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)

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Accession:135903
"... Here we demonstrate, via a detailed computational model, a mechanism whereby physiological noise and coupling initiate oscillations and then recruit neighboring tissue, in a manner well described by a combination of Stochastic Resonance and Coherence Resonance. We develop a novel statistical method to quantify recruitment using several measures of network synchrony. This measurement demonstrates that oscillations spread via preexisting network connections such as interneuronal connections, recurrent synapses, and gap junctions, provided that neighboring cells also receive sufficient inputs in the form of random synaptic noise. ..."
Reference:
1 . Stacey WC, Krieger A, Litt B (2011) Network recruitment to coherent oscillations in a hippocampal computer model. J Neurophysiol 105:1464-81 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Stacey, William [wstacey at med.umich.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I h;
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
//  NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2010, The University Of Michigan
// 	
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   No Distribution without permission of William Stacey
//   wstacey@umich.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

//This is for the basket cells based on the paper
// 
// Tort, A. B., Rotstein, H. G., Dugladze, T., et al. (2007). On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus. Proc Natl Acad Sci U S A,.
//   

{load_file("syn.tem")}
{load_file("gap.tem")}
{load_file("iapp.tem")}

begintemplate Bwb

external cvode

// PUBLIC VARIABLES
public x, y, z

// PUBLIC OBJECTS
public soma, spiketimes, idvec, synS, gapS, iappS, synlist, recordT, voltageRecS 

//PUBLIC METHODS
public position, getlocoS, connect2target, recordVoltage, is_art, addSynS, getTotalArea
public setScatteredVoltages, writeVoltage

create soma    

objref iappS, synS, gapS, locS, voltageRecS, recordT
objref spiketimes, idvec, nil, synlist

strdef cmd

// =================================================================================================
//
// init(mean, sd, isUnitsPerCm2, gid)
//
// =================================================================================================
proc init() {
    
    createCell()
        
    access soma
    
    synlist = new List()
    locS    = new SectionRef()
    iappS   = new IApp()
    synS    = new SynObj()
    gapS    = new GapObj()
    
    spiketimes  = new Vector()
    idvec       = new Vector()
    voltageRecS = new Vector()
    recordT     = new Vector()
    
    iappS.set_random_play($2, $3, $4, $1)
}






// =================================================================================================
//
// recordVoltage()
//
// =================================================================================================
proc recordVoltage() {
		
		//print "Started RECORDING VOLTAGE at Bask"	
		soma  cvode.record(&v(0.5), voltageRecS, recordT )
		//soma  cvode.record(&iappS.iappR.amp, voltageRecS, recordT )
}





// =================================================================================================
//
// writeVoltage(gid)
//
// =================================================================================================
proc writeVoltage() { local i localobj fo, m

	//print "SIZE:", t, " ", recordT.size()

	m = new Matrix(recordT.size(), 6)

	m.setcol(0, recordT)
	m.setcol(1, voltageRecS)

	fo = new File()
	
	sprint(cmd, "data/%d.dat", $1)
	
	{fo.wopen(cmd)}
	
	{m.fprint(0, fo, "%6.3lf ")}
	
	{fo.close()}
}




// ========================================================================
//
// getTotalArea()
//
// ========================================================================
func getTotalArea() {
	
	return totalArea
}




// =================================================================================================
//
// connect2target()
//
// =================================================================================================
proc connect2target() { //$o1 target point process, $o2 returned NetCon
  
  soma $o2 = new NetCon(&v(0.5), $o1, 0 ,0, 0)
  
  if (numarg()==2) synS.addNetCon($o2)
}



// =================================================================================================
//
// createCell()
//
// =================================================================================================
proc createCell() {

    totalArea = 100 // um2

    soma {
        nseg  = 1
        cm    = 1      // uF/cm2
        diam  = sqrt(totalArea) // um
        L     =  diam/PI  // um
    
        insert pas
            e_pas = -65     // mV
            g_pas = 0.1e-3  // S/cm2 
  
        insert Nafbwb
        insert Kdrbwb
    }
}




// ========================================================================
//
// addSynS( tau1 (ms), tau2 (ms), Erev (mV), synapseName, synLoc )
//
// ========================================================================
func addSynS() {
    
    synlist.append(synS.synList.object( synS.addSyn( $1, $2, $3, $s4, $5)  ) )
	return synlist.count()-1
}




// =================================================================================================
//
// setScatteredVoltages(low, high)
//
// =================================================================================================
proc setScatteredVoltages() { localobj rand

  rand = new Random(startsw())
  rand.uniform($1,$2)

  forall v = rand.repick()
}




// =================================================================================================
//
// getlocoS()
//
// =================================================================================================
obfunc getlocoS() { return locS }






// =================================================================================================
//
// position()
//
// =================================================================================================
proc position() { x=$1 y=$2 z=$3 }




// =================================================================================================
//
// is_art()
//
// =================================================================================================
func is_art() { return 0}




endtemplate Bwb