Network recruitment to coherent oscillations in a hippocampal model (Stacey et al. 2011)

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Accession:135903
"... Here we demonstrate, via a detailed computational model, a mechanism whereby physiological noise and coupling initiate oscillations and then recruit neighboring tissue, in a manner well described by a combination of Stochastic Resonance and Coherence Resonance. We develop a novel statistical method to quantify recruitment using several measures of network synchrony. This measurement demonstrates that oscillations spread via preexisting network connections such as interneuronal connections, recurrent synapses, and gap junctions, provided that neighboring cells also receive sufficient inputs in the form of random synaptic noise. ..."
Reference:
1 . Stacey WC, Krieger A, Litt B (2011) Network recruitment to coherent oscillations in a hippocampal computer model. J Neurophysiol 105:1464-81 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Stacey, William [wstacey at med.umich.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA1 interneuron oriens alveus GABA cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I h;
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
//  NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2010, The University Of Michigan
// 	
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   No Distribution without permission of William Stacey
//   wstacey@umich.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

// ### This file is not obsolete.  The gap junctions are placed within TGnet.tem using a different method.###

begintemplate GapObj

public add, get, getloc, addVar, remove_all, addPerArea, gapList

objref  gapList, loc
        



// =================================================================================================
//
// init()
//
// =================================================================================================
proc init() {
    gapList = new List()
    loc = new SectionRef()
}




// =================================================================================================
//
// add(sec ref preSynCell, ggap (nS))
//
// =================================================================================================
proc add() {
    
    if (numarg()==1) {
    
        loc.sec gapList.prepend(new HalfGap(0.5))
        
        gapList.object(0).g = $1
        //$o1.sec setpointer gapList.object(0).vgap, v(0.5)
        
    }else{
    
        print "USAGE: add(sec ref preSynCell, ggap (nS))"
    
    }
}




// =================================================================================================
//
// addPerArea(sec ref preSynCell, ggap (mS/cm2))
//
// =================================================================================================
proc addPerArea() {
    
    if (numarg()==2) {
    
        loc.sec gapList.prepend(new HalfGap(0.5))
        
        loc.sec gapList.object(0).ggap = $2 * area(0.5) * 1e-2 // -> nS 1e-8 * 1e6
        $o1.sec setpointer gapList.object(0).vgap, v(0.5)
        
    }else{
    
        print "USAGE: add(sec ref preSynCell, ggap (mS/cm2))"
    
    }
}



// =================================================================================================
//
// remove_all()
//
// ================================================================================================
proc remove_all() {

    gapList.remove_all()
}




// =================================================================================================
//
// addVar()
//
// ================================================================================================
proc addVar() {
    
    if (numarg()==2) {
    
        loc.sec gapList.prepend(new HalfGap(0.5))
        
        gapList.object(0).ggap = $2
        loc.sec setpointer gapList.object(0).vgap, $&1
        
    }else{
    
        print "USAGE: addGap(&var, ggap (nS))"
    
    }
}




// =================================================================================================
//
// getloc()
//
// ================================================================================================
proc getloc() {
    
    loc.sec print secname() 
}




// =================================================================================================
//
// get()
//
// ================================================================================================
proc get() {

    for i=0, gapList.count()-1 {
        loc.sec printf("%d, %s, vpre= %s, ggap= %g uS, loc= %s\n", i, gapList.object(i), gapList.object(i).vpre, gapList.object(i).ggap, secname())
    }
}

endtemplate GapObj