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Functional structure of mitral cell dendritic tuft (Djurisic et al. 2008)
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The computational modeling component of Djurisic et al. 2008 addressed two primary questions: whether amplification by active currents is necessary to explain the relatively mild attenuation suffered by tuft EPSPs spreading along the primary dendrite to the soma; what accounts for the relatively uniform peak EPSP amplitude throughout the tuft. These simulations show that passive spread from tuft to soma is sufficient to yield the low attenuation of tuft EPSPs, and that random distribution of a biologically plausible number of excitatory synapses throughout the tuft can produce the experimentally observed uniformity of depolarization.
Djurisic M, Popovic M, Carnevale N, Zecevic D (2008) Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb.
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Neuron or other electrically excitable cell;
Olfactory bulb main mitral GLU cell;
Dendritic Action Potentials;
Carnevale, Ted [Ted.Carnevale at Yale.edu];
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Olfactory bulb main mitral GLU cell
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Passive tuft, Ra = 2*control
Passive tuft, both 2*control
Passive tuft, cm = 2*control
Passive tuft, control