Functional structure of mitral cell dendritic tuft (Djurisic et al. 2008)

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The computational modeling component of Djurisic et al. 2008 addressed two primary questions: whether amplification by active currents is necessary to explain the relatively mild attenuation suffered by tuft EPSPs spreading along the primary dendrite to the soma; what accounts for the relatively uniform peak EPSP amplitude throughout the tuft. These simulations show that passive spread from tuft to soma is sufficient to yield the low attenuation of tuft EPSPs, and that random distribution of a biologically plausible number of excitatory synapses throughout the tuft can produce the experimentally observed uniformity of depolarization.
1 . Djurisic M, Popovic M, Carnevale N, Zecevic D (2008) Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb. J Neurosci 28:4057-68 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell;
Channel(s): I K; I Sodium;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Synaptic Integration; Olfaction;
Implementer(s): Carnevale, Ted [Ted.Carnevale at];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; I K; I Sodium;
// $Id: init_active.hoc,v 1.2 2008/04/30 21:01:14 ted Exp ted $

// POPOVIC = 1  // use cell params from Popovic et al., 2005

Based on init_spiketuft.hoc

Active mitral cell model, stimulated at the soma, 
to investigate spike invasion of the tuft.
Biophysical parameters are as in
Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) 
Computational Analysis of Action Potential Initiation in Mitral Cell Soma and 
Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006,
which is available from ModelDB (accession number 3342, URL ).

This version does not include their complex model axon, 
because the tuft is so far from the site of axonal attachment 
that axonal details probably have no effect on it.

Displays peak amplitude of the spike throughout the tuft.


if (POPOVIC) {
} else {


forall {
  ena = 60
  ek = -90

/* don't bother with this
load_file("fixgrid_spiketuft.hoc")  // turn off Continuous Create
  // then double Ra and cm, regrid the model using d_lambda rule, and finally restore Ra and cm

load_file("")  // RunControl, v graph, and IClamp at soma
load_file("instrument_spiketuft.hoc")  // inserts monx and computes distances over tuft subset
// this active cell makes its own spikes
// load_file("spikeclamp_spiketuft.hoc")  // puts an SEClamp at origin of tuft
  // that will be used to drive this point with a recorded spike waveform
// load_file("analyze_spiketuft.hoc")  // analyze results
load_file("analyze_active.hoc")  // analyze results
// load_file("plots_spiketuft.hoc")  // display results
load_file("plots_active.hoc")  // display results
// load_file("control_spiketuft.hoc")  // execute simulation, control analysis, display, and storage of results
load_file("control_active.hoc")  // execute simulation, control analysis, display, and storage of results