Modeling local field potentials (Bedard et al. 2004)

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Accession:136310
This demo simulates a model of local field potentials (LFP) with variable resistivity. This model reproduces the low-pass frequency filtering properties of extracellular potentials. The model considers inhomogeneous spatial profiles of conductivity and permittivity, which result from the multiple media (fluids, membranes, vessels, ...) composing the extracellular space around neurons. Including non-constant profiles of conductivity enables the model to display frequency filtering properties, ie slow events such as EPSPs/IPSPs are less attenuated than fast events such as action potentials. The demo simulates Fig 6 of the paper.
Reference:
1 . Bédard C, Kröger H, Destexhe A (2004) Modeling extracellular field potentials and the frequency-filtering properties of extracellular space. Biophys J 86:1829-42 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Connectionist Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Extracellular Fields;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
 
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LFP
README
ImpedanceFM.mod
calc_lfp_variable-resistivity.oc
curr.dat
mosinit.hoc
                            
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