Biophysically realistic neural modeling of the MEG mu rhythm (Jones et al. 2009)

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Accession:136803
"Variations in cortical oscillations in the alpha (7–14 Hz) and beta (15–29 Hz) range have been correlated with attention, working memory, and stimulus detection. The mu rhythm recorded with magnetoencephalography (MEG) is a prominent oscillation generated by Rolandic cortex containing alpha and beta bands. Despite its prominence, the neural mechanisms regulating mu are unknown. We characterized the ongoing MEG mu rhythm from a localized source in the finger representation of primary somatosensory (SI) cortex. Subjects showed variation in the relative expression of mu-alpha or mu-beta, which were nonoverlapping for roughly 50% of their respective durations on single trials. To delineate the origins of this rhythm, a biophysically principled computational neural model of SI was developed, with distinct laminae, inhibitory and excitatory neurons, and feedforward (FF, representative of lemniscal thalamic drive) and feedback (FB, representative of higher-order cortical drive or input from nonlemniscal thalamic nuclei) inputs defined by the laminar location of their postsynaptic effects. ..."
Reference:
1 . Jones SR, Pritchett DL, Sikora MA, Stufflebeam SM, Hämäläinen M, Moore CI (2009) Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses. J Neurophysiol 102:3554-72 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell;
Channel(s): I Na,t; I T low threshold; I K; I h;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Touch;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; GabaA; GabaB; AMPA; NMDA; I Na,t; I T low threshold; I K; I h;
//Feed to Excitatory FeedtoXX(seg,rtype,maxW,WSC,minD,DSC,fobj)
//Feed to Inhibitory FeedtoXXX(rtype,maxW,WSC,minD,DSC,fobj)
//ExctoExc XtoX(maxW,WSC,seg,rtype,minD,DSC)
//ExctoInh XtoX(maxW,WSC,minD,DSC,rtype)
//Feeds taken out

IItoII(0.0005,3,1,0,1,3) 
IItoII(0.0005,3,5,0,1,3)
IItoII(0.0005,3,6,0,1,3)
IItoII(0.0005,3,1,1,1,3)
IItoII(0.0005,3,5,1,1,3)
IItoII(0.0005,3,6,1,1,3)

IItoV(0.00025,3,1,0,3,3) // WSC=3->1
IItoV(0.00025,3,6,0,3,3)
IItoV(0.00025,3,7,0,3,3)
IItoV(0.00025,3,4,0,3,3) //from 0.00025

IItoIL2(0.0005,3,1,3,0) // from .01 

IItoIL5(0.00025,3,1,3,0) // from .00025

//InhtoExh XtoX(seg,rtype,maxW,WSC,minD,DSC)
//InhtoInh XtoX(maxW,WSC,minD,DSC,rtype)

IL2toII(7,2,0.05,50,1,50) // from .05
IL2toII(7,3,0.05,50,1,50) //   "

IL2toV(4,2,0.001,50,1,50) //  from .001 

IL2toIL2(0.02,20,1,20,2) // 

VtoV(0.0005,3,6,0,1,3) //0.005
VtoV(0.0005,3,7,0,1,3)  
VtoV(0.0005,3,1,0,1,3)	
VtoV(0.0005,3,6,1,1,3) 
VtoV(0.0005,3,7,1,1,3) //0.0005
VtoV(0.0005,3,1,1,1,3)

VtoIL5(0.0005,3,1,3,0) // from .001

IL5toV(8,2,0.025,70,1,70) //from 0.025
IL5toV(8,3,0.025,70,1,70)

IL5toIL5(0.02,20,1,20,2)