Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)

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Accession:138321
Transcranial magnetic stimulation (TMS) is a widely applied tool for probing cognitive function in humans and is one of the best tools for clinical treatments and interfering with cognitive tasks. Surprisingly, while TMS has been commercially available for decades, the cellular mechanisms underlying magnetic stimulation remain unclear. Here we investigate these mechanisms using compartmental modeling. We generated a numerical scheme allowing simulation of the physiological response to magnetic stimulation of neurons with arbitrary morphologies and active properties. Computational experiments using this scheme suggested that TMS affects neurons in the central nervous system (CNS) primarily by somatic stimulation.
Reference:
1 . Pashut T, Wolfus S, Friedman A, Lavidor M, Bar-Gad I, Yeshurun Y, Korngreen A (2011) Mechanisms of magnetic stimulation of central nervous system neurons. PLoS Comput Biol 7:e1002022 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell; Squid axon;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Action Potential Initiation; Magnetic stimulation;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com]; Pashut, Tamar [tamar.pashut at gmail.com];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell;
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pashut2011
TwoDimensions
Neuron
cells
cad2.mod *
child.mod *
childa.mod *
epsp.mod *
it2.mod *
kaprox.mod *
kca.mod *
km.mod *
kv.mod *
na.mod *
SlowCa.mod *
xtra.mod *
alon.ses
BACModel.hoc
BACModel_mag.hoc
Display.ses *
magstim.hoc
                            
NEURON {
	SUFFIX xtra
	RANGE rx, is
	RANGE x, y, z, XX, YY, DX,DY, FX, FY, Exs, Exf, Eys,Eyf
	RANGE DEDA
	NONSPECIFIC_CURRENT i_m
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(um) = (micron)
} 

PARAMETER {
	x = 0 (um) : spatial coords  in microns
	y = 0 (um)
	z = 0 (um)
	XX = 0 (um)
	YY = 0 (um)
	FX = 0 (um)
	FY = 0 (um)
	DX=0 (um)
	DY=0 (um)
	Exs=0  (V millisec/m amp)
	Exf=0  (V millisec/m amp)
	Eys=0  (V millisec/m amp)
	Eyf=0  (V millisec/m amp)
	DEDA=0  (V millisec/m um amp)
}

ASSIGNED {
	rx  (millisec/m2)
	is  (amp/millisec)
	i_m (milliamp/cm2)
}

INITIAL {
	i_m=0
}

BREAKPOINT{
	i_m=-(0.1)*rx*is
}