"Abnormalities in oscillations have been suggested to play a role in schizophrenia.
We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and
without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic.
Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare,
OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells
primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta.
Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts theta modulation of gamma in a computer model of hippocampus Journal of Neuroscience 31(32):11733-11743 [PubMed]