" ... Using electron microscopy and serial reconstructions, we analyzed the dendritic trees of
four morphologically distinct neocortical interneuron subtypes to reveal two underlying organizational
principles common to all.
First, cross-sectional areas at any given point within a dendrite were proportional
to the summed length of all dendritic segments distal to that point.
...
Second, dendritic cross-sections
became progressively more elliptical at more proximal, larger diameter, dendritic locations.
Finally,
computer simulations revealed that these conserved morphological features limit distance dependent
filtering of somatic EPSPs and facilitate distribution of somatic depolarization into all dendritic
compartments.
..."
Reference:
1 .
Kubota Y, Karube F, Nomura M, Gulledge AT, Mochizuki A, Schertel A, Kawaguchi Y (2011) Conserved properties of dendritic trees in four cortical interneuron subtypes. Sci Rep 1:89 [PubMed]
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