Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:140462
Inward and outward currents of the olfactory bulb juxtaglomerular cells are characterized in the experiments and modeling in these two Masurkar and Chen 2011 papers.
Reference:
1 . Masurkar AV, Chen WR (2011) Calcium currents of olfactory bulb juxtaglomerular cells: profile and multiple conductance plateau potential simulation. Neuroscience 192:231-46 [PubMed]
2 . Masurkar AV, Chen WR (2011) Potassium currents of olfactory bulb juxtaglomerular cells: characterization, simulation, and implications for plateau potential firing. Neuroscience 192:247-62 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main interneuron periglomerular GABA cell; Olfactory bulb main juxtaglomerular cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I Calcium; I Potassium; I_KHT;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Olfaction;
Implementer(s): Masurkar, Arjun [avmasurkar at gmail.com];
Search NeuronDB for information about:  Olfactory bulb main interneuron periglomerular GABA cell; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I Calcium; I Potassium; I_KHT;
// pulse.hoc
// add pulse generator Ipulse2 from
// http://www.neuron.yale.edu/neuron/static/docs/repstim/pulsedistrib.zip

objref ip
soma ip=new Ipulse2(0.5)
ip.del=100
ip.dur=10  // duration of pulse
ip.per=240 // period of pulse
ip.num=4
ip.amp=0 // set to .3 when creating figure 7c

proc set_period() {
  ip.per=$1
  tstop=4*ip.per+2*ip.del
}

xpanel("run pulse generator")
  xlabel("Click below to generate traces for")
  xbutton("Figure 7c Marsurkar, Chen 2011 (Ca2+)","fig7c()")
xpanel()

objref vbox, g1, g2
objref v_vec, t_vec
proc fig7c() {
  vbox=new VBox()
  vbox.intercept(1)
    g1=new Graph()
    set_period(240)
    v_vec=new Vector()
    t_vec=new Vector()
    v_vec.record(&soma.v(0.5))
    t_vec.record(&t)

    store_iclamp=IClamp[0].amp
    IClamp[0].amp=0
    ip.amp=.3

    init()
    run()
    v_vec.line(g1, t_vec)
    g1.exec_menu("View = plot")
    g2=new Graph()
    set_period(130)
    v_vec=new Vector()
    t_vec=new Vector()
    v_vec.record(&soma.v(0.5))
    t_vec.record(&t)
    init()
    run()

    IClamp[0].amp=store_iclamp
    ip.amp=0 // turn off pulses in case want to run IClamp

    v_vec.line(g2, t_vec)
    g2.exec_menu("View = plot")
  vbox.intercept(0)
vbox.map()
}