We localize a single neuron from the spatial sample of its EAP
amplitudes recorded with a multisite probe (with 6 or more independent
measurement sites or channels, e.g., a silicon polytrode, a stepped
tetrode, etc.) This is an inverse problem and we solve it by fitting a
model to the EAPs that consists of a volume conductor model of the
neural tissue (known), a realistic model of the probe (known), and a
single dipole current source of the model neuron (unknown). The dipole
is free to change position, size, and orientation (a total of 6
parameters) at each moment during the action potential.
Reference:
1 .
Mechler F, Victor JD (2012) Dipole characterization of single neurons from their extracellular action potentials. J Comput Neurosci 32:73-100 [PubMed]
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