Motoneuron model of self-sustained firing after spinal cord injury (Kurian et al. 2011)

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Accession:140788
" ... During the acute-stage of spinal cord injury (SCI), the endogenous ability to generate plateaus is lost; however, during the chronic-stage of SCI, plateau potentials reappear with prolonged self-sustained firing that has been implicated in the development of spasticity. In this work, we extend previous modeling studies to systematically investigate the mechanisms underlying the generation of plateau potentials in motoneurons, including the influences of specific ionic currents, the morphological characteristics of the soma and dendrite, and the interactions between persistent inward currents and synaptic input. ..."
Reference:
1 . Kurian M, Crook SM, Jung R (2011) Motoneuron model of self-sustained firing after spinal cord injury. J Comput Neurosci 31:625-45 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,p; I K,Ca; I CAN; I Sodium; I Potassium; I Ca,p;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP; MATLAB;
Model Concept(s): Simplified Models; Active Dendrites; Intrinsic plasticity; Synaptic Integration;
Implementer(s): Kurian, Mini ; Crook, Sharon ;
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I K,Ca; I CAN; I Sodium; I Potassium; I Ca,p;
 
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