Phase response curve of a globus pallidal neuron (Fujita et al. 2011)

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Accession:143100
We investigated how changes in ionic conductances alter the phase response curve (PRC) of a globus pallidal (GP) neuron and stability of a synchronous activity of a GP network, using a single-compartmental conductance-based neuron model. The results showed the PRC and the stability were influenced by changes in the persistent sodium current, the Kv3 potassium, the M-type potassium and the calcium-dependent potassium current.
Reference:
1 . Fujita T, Fukai T, Kitano K (2012) Influences of membrane properties on phase response curve and synchronization stability in a model globus pallidus neuron. J Comput Neurosci 32:539-53 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Globus pallidus neuron;
Channel(s): I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Ions;
Simulation Environment: NEURON;
Model Concept(s): Synchronization; Parkinson's; Phase Response Curves;
Implementer(s): Kitano, Katsunori [kitano at ci.ritsumei.ac.jp];
Search NeuronDB for information about:  I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1; Ions;
TITLE calcium dynamics for GPe neuron

COMMENT

ENDCOMMENT

NEURON {
 SUFFIX Calcium
 USEION ca READ ica WRITE cai
 RANGE a2v
}

UNITS {
 (mM) = (milli/liter)
 (mA) = (milliamp)
 (um) = (microm)
 F = (faraday)(coulomb)
}

PARAMETER {
 dt (ms)
 z = 2.0
 kca = 0.4 (1/ms)
 cai0 = 0.00001 (mM)
 a2v = 3000.0 (1/cm)
}

ASSIGNED {
 ica (mA/cm2)
 alpha
}

STATE {
 cai (mM)
}

BREAKPOINT {
 SOLVE integrate METHOD cnexp
}

UNITSOFF

INITIAL{
 alpha = a2v/(z*F)
 cai = cai0
}

DERIVATIVE integrate {
 cai' = -alpha*ica - kca*(cai - cai0)
}

UNITSON