Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)

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Accession:143604
A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Reference:
1 . Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013) Compartmentalization of GABAergic inhibition by dendritic spines. Science 340:759-62 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s): I Na,t; I L high threshold; I K;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Influence of Dendritic Geometry;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; I Na,t; I L high threshold; I K;
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singleDendrite
mod
ca.mod
ca_a1g.mod
ca_a1h.mod *
cad.mod
constant.mod
distr.mod *
exp2syncur.mod
exp2synsat.mod
im.mod *
kca.mod *
km.mod *
kv.mod
multiclamp.mod
na.mod
zoidsyn.mod *
                            
TITLE ...just to store peak membrane voltage
: M.Migliore June 2001
: T Morse February 2010 added times of occurence

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v (mV)
}


NEURON {
	SUFFIX ds
        RANGE vmax, tmax
}

ASSIGNED {
	vmax
	tmax
}

INITIAL {
	vmax=v
}


BREAKPOINT {
	if (v>vmax) {vmax=v tmax=t}
}