Thalamic network model of deep brain stimulation in essential tremor (Birdno et al. 2012)

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Accession:143633
"... Thus the decreased effectiveness of temporally irregular DBS trains is due to long pauses in the stimulus trains, not the degree of temporal irregularity alone. We also conducted computer simulations of neuronal responses to the experimental stimulus trains using a biophysical model of the thalamic network. Trains that suppressed tremor in volunteers also suppressed fluctuations in thalamic transmembrane potential at the frequency associated with cerebellar burst-driver inputs. Clinical and computational findings indicate that DBS suppresses tremor by masking burst-driver inputs to the thalamus and that pauses in stimulation prevent such masking. Although stimulation of other anatomic targets may provide tremor suppression, we propose that the most relevant neuronal targets for effective tremor suppression are the afferent cerebellar fibers that terminate in the thalamus."
Reference:
1 . Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM (2012) Stimulus features underlying reduced tremor suppression with temporally patterned deep brain stimulation. J Neurophysiol 107:364-83 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Axon;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; Glutamate; Gaba;
Gene(s):
Transmitter(s): Gaba; Ions;
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Action Potential Initiation; Temporal Pattern Generation; Axonal Action Potentials; Therapeutics; Deep brain stimulation;
Implementer(s):
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; GabaA; GabaB; AMPA; NMDA; Glutamate; Gaba; Gaba; Ions;
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Birdno_et_al_2012
master
modfiles
README.txt
setup.q
startruna.q
                            
This is the README for the model associated with the paper:

Birdno MJ, Kuncel AM, Dorval AD, Turner DA, Gross RE, Grill WM (2012)
Stimulus features underlying reduced tremor suppression with
temporally patterned deep brain stimulation. J Neurophysiol 107:364-83

Thalamic Network Model
Merrill J. Birdno
May 2009

TC Neuron Derived from McIntyre et.el., 2004

BASIC INSTRUCTIONS:

1) You will need to use mknrn.dll (see NEURON documentation)(MAC or
mswin) or nrnivmodl (unix/linux) to create a new 'special' file with
the compiled .mod mechanisms. Copy this special file into the 'master'
simulation directory included with the model.

2) ~Line 627 in DBSstim.hoc, you will see the line:

		indrt = strobj.tail(subdir,"ModelDirectory/","x")
	
	You will need to change "ModelDiretory/" to "SuperDirectory/"
	where SuperDirectory is the directory that contains the master
	directory and all of your sim run directories.  Make sure the
	directory ends with a slash.

3) Use setup.q script to create multiple "sim" directories for your
simulation runs and load the appropriate model/stimulus
parameters. This will also copy your special file into the
directories.

4) Run the model using the command: ./special DBSstim.hoc quit.hoc
from inside each newly created directory.

5) DBSstim.hoc loads several parameter files at the beginning, which
is why you need the nk, vsh.txt, etc. files in each run directory.

6) If you would like to custumize the extracellular stimulus trains
played into the model, then you will need to generate Harmaline.dat,
Poisson.dat, and Stim_x.dat files in master directory using
generate_stim_poisson_harmaline.m file.