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Hodgkin-Huxley model of persistent activity in PFC neurons (Winograd et al. 2008) (NEURON python)
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The paper demonstrate a form of graded persistent activity activated by hyperpolarization. This phenomenon is modeled based on a slow calcium regulation of Ih, similar to that introduced earlier for thalamic neurons (see Destexhe et al., J Neurophysiol. 1996). The only difference is that the calcium signal is here provided by the high-threshold calcium current (instead of the low-threshold calcium current in thalamic neurons).
Winograd M, Destexhe A, Sanchez-Vives MV (2008) Hyperpolarization-activated graded persistent activity in the prefrontal cortex.
Proc Natl Acad Sci U S A
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Neuron or other electrically excitable cell;
Prefrontal cortex (PFC);
I L high threshold;
Ion Channel Kinetics;
Skolnick, Yosef [yskolnick at gmail.com];
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I L high threshold
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HPGA non-saturating (no Ih)