Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:144520
"Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental work ..."
Reference:
1 . DiFrancesco D, Noble D (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307:353-98 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cardiac atrial cell; Cardiac ventricular cell;
Channel(s): I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s): HCN4;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Gannier, Francois [francois.gannier at univ-tours.fr];
Search NeuronDB for information about:  I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
objectvar save_window_, rvp_
objectvar scene_vector_[3]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}

//Begin Insert/Remove Mechanisms
{
load_file("inserter.hoc", "Inserter")
}
{
soma ocbox_ = new Inserter(0)
}
{object_push(ocbox_)}
{
mt.select("pas") i = mt.selected()
ms[i] = new MechanismStandard("pas")
mstate[i]= 0
mt.select("hh") i = mt.selected()
ms[i] = new MechanismStandard("hh")
mstate[i]= 0
mt.select("Cadynam") i = mt.selected()
ms[i] = new MechanismStandard("Cadynam")
mstate[i]= 1
maction(i)
mt.select("ibg") i = mt.selected()
ms[i] = new MechanismStandard("ibg")
mstate[i]= 1
maction(i)
mt.select("ifun") i = mt.selected()
ms[i] = new MechanismStandard("ifun")
mstate[i]= 1
maction(i)
mt.select("ik1") i = mt.selected()
ms[i] = new MechanismStandard("ik1")
mstate[i]= 1
maction(i)
mt.select("ikd") i = mt.selected()
ms[i] = new MechanismStandard("ikd")
mstate[i]= 1
maction(i)
mt.select("inaca") i = mt.selected()
ms[i] = new MechanismStandard("inaca")
mstate[i]= 1
maction(i)
mt.select("INaf") i = mt.selected()
ms[i] = new MechanismStandard("INaf")
mstate[i]= 1
maction(i)
mt.select("inak") i = mt.selected()
ms[i] = new MechanismStandard("inak")
mstate[i]= 1
maction(i)
mt.select("Isi") i = mt.selected()
ms[i] = new MechanismStandard("Isi")
mstate[i]= 1
maction(i)
mt.select("ito") i = mt.selected()
ms[i] = new MechanismStandard("ito")
mstate[i]= 1
maction(i)

mt.select("K_acc") i = mt.selected()
ms[i] = new MechanismStandard("K_acc")
mstate[i]= 1
maction(i)

mt.select("Na_acc") i = mt.selected()
ms[i] = new MechanismStandard("Na_acc")
mstate[i]= 1
maction(i)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("Insert/Remove Mechanisms", 528, 0, 100, 250)
}
objref ocbox_
//End Insert/Remove Mechanisms

{WindowMenu[0].ses_gid(0, 0, 1, "Init")}
{
xpanel("RunControl", 0)
v_init = -80
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1000
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 0
xvalue("t","t", 2 )
tstop = 1500
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 59.817
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 1
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 0.75
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(0,460)
}
{WindowMenu[0].ses_gid(0, 0, 1, "Init")}
objectvar scene_vector_[1]
{doNotify()}