CA1 pyramidal neuron: Ih current (Migliore et al. 2012)

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Accession:144541
NEURON files from the paper: Migliore M, Migliore R (2012) Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations. PLoS ONE 7(5): e36867. doi:10.1371/journal.pone.0036867. Experimental findings on the effects of Ih current modulation, which is particularly involved in epilepsy, appear to be inconsistent. In the paper, using a realistic model we show how and why a shunting current, such as that carried by TASK-like channels, dependent on the Ih peak conductance is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions.
Reference:
1 . Migliore M, Migliore R (2012) Know your current I(h): interaction with a shunting current explains the puzzling effects of its pharmacological or pathological modulations. PLoS One 7:e36867 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Channel/Receptor;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Epilepsy; Synaptic Integration;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I A; I K; I M; I h; I Potassium;
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Ih_current
readme.html
distr.mod *
h.mod *
kadist.mod
kaprox.mod
kdrca1.mod
km.mod
na3n.mod
naxn.mod
fig-5a.hoc
fixnseg.hoc *
mosinit.hoc
ri06.hoc
screenshot.png
                            
TITLE CA1 KM channel from Mala Shah
: M. Migliore June 2006

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v 		(mV)
	ek
	celsius 	(degC)
	gbar=.0001 	(mho/cm2)
        vhalfl=-40   	(mV)
	kl=-10
        vhalft=-42   	(mV)
        a0t=0.009      	(/ms)
        zetat=7    	(1)
        gmt=.4   	(1)
	q10=5
	b0=60
	st=1
}


NEURON {
	THREADSAFE SUFFIX km
	USEION k READ ek WRITE ik
        RANGE  gbar,ik
      GLOBAL inf, tau
}

STATE {
        m
}

ASSIGNED {
	ik (mA/cm2)
        inf
	tau
        taua
	taub
}

INITIAL {
	rate(v)
	m=inf
}


BREAKPOINT {
	SOLVE state METHOD cnexp
	ik = gbar*m^st*(v-ek)
}


FUNCTION alpt(v(mV)) {
  alpt = exp(0.0378*zetat*(v-vhalft)) 
}

FUNCTION bett(v(mV)) {
  bett = exp(0.0378*zetat*gmt*(v-vhalft)) 
}

DERIVATIVE state {
        rate(v)
:        if (m<inf) {tau=taua} else {tau=taub}
	m' = (inf - m)/tau
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-35)/10)
        inf = (1/(1 + exp((v-vhalfl)/kl)))
        a = alpt(v)
        tau = b0 + bett(v)/(a0t*(1+a))
:        taua = 50
:        taub = 300
}