Boolean network-based analysis of the apoptosis network (Mai and Liu 2009)

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Accession:144586
"To understand the design principles of the molecular interaction network associated with the irreversibility of cell apoptosis and the stability of cell surviving, we constructed a Boolean network integrating both the intrinsic and extrinsic pro-apoptotic pathways with pro-survival signal transduction pathways. We performed statistical analyses of the dependences of cell fate on initial states and on input signals. The analyses reproduced the well-known pro- and anti-apoptotic effects of key external signals and network components. We found that the external GF signal by itself did not change the apoptotic ratio from randomly chosen initial states when there is no external TNF signal, but can significantly offset apoptosis induced by the TNF signal. ..."
Reference:
1 . Mai Z, Liu H (2009) Boolean network-based analysis of the apoptosis network: irreversible apoptosis and stable surviving. J Theor Biol 259:760-9 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism: Generic;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Methods; Signaling pathways; Boolean network; Apoptosis;
Implementer(s): Neymotin, Sam [Samuel.Neymotin at nki.rfmh.org];
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readme.html
bnet.mod
misc.mod *
stats.mod *
vecst.mod *
apopnames.txt
apoprules.txt
bnet.py
dbgnames.txt
dbgrules.txt
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
grvec.hoc *
init.hoc
local.hoc *
misc.h *
misc.py *
mosinit.py
netstate.gif
network.py
nqs.hoc *
nrnoc.hoc *
pyinit.py *
python.hoc
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simctrl.hoc *
snutils.py
                            
# $Id: pyinit.py,v 1.2 2012/02/15 16:22:52 samn Exp $ 

from neuron import h
import os
import sys
import datetime
import shutil
import pickle
from math import sqrt, pi
import numpy
import types

h("objref p")
h("p = new PythonObject()")

try:
    import pylab
    from pylab import plot, arange, figure
    my_pylab_loaded = True
except ImportError:
    print "Pylab not imported"
    my_pylab_loaded = False

def htype (obj): st=obj.hname(); sv=st.split('['); return sv[0]
def secname (obj): obj.push(); print h.secname() ; h.pop_section()
def psection (obj): obj.push(); print h.psection() ; h.pop_section()

allsecs=None #global list containing all NEURON sections, initialized via mkallsecs

# still need to generate a full allsecs
def mkallsecs ():
  """ mkallsecs - make the global allsecs variable, containing
      all the NEURON sections.
  """
  global allsecs
  allsecs=h.SectionList() # no .clear() command
  roots=h.SectionList()
  roots.allroots()
  for s in roots:
    s.push()
    allsecs.wholetree()
  return allsecs

#forall syntax - c gets executed, allsecs has Sections
def forall (c):
    """ NEURON forall syntax - iterates through all the sections available
        note that there's a dummy loop variable called s used in this function,
        so any command that needs to access a section should be via s.
        example: forall('print s.name()') , will print all the section names.
        Also note that this function uses a global list, 'allsecs', which may
        need to get re-initialized when new sections are created, via the mkallsecs
        function above.
    """
    global allsecs
    if (type(allsecs)==types.NoneType): mkallsecs()
    for s in allsecs: exec(c)

#forsec syntax - executes command for each section who's name
# contains secname as a substring
def forsec (secref="soma",command=""): 
    """ NEURON forsec syntax - iterates over all sections which have a substring
        in their names matching secref argument. command is executed if match found.
        this function also utilizes the allsecs global variable.
    """
    global allsecs
    if (type(allsecs)==types.NoneType): mkallsecs()
    if (type(secref)==types.StringTypes[0]):
        for s in allsecs:
            if s.name().count(secref) > 0:
                exec(command)
    else:
        for s in secref: exec(command)