A set of reduced models of layer 5 pyramidal neurons (Bahl et al. 2012)

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Accession:146026
These are the NEURON files for 10 different models of a reduced L5 pyramidal neuron. The parameters were obtained by automatically fitting the models to experimental data using a multi objective evolutionary search strategy. Details on the algorithm can be found at http://www.g-node.org/emoo and in Bahl et al. (2012).
Reference:
1 . Bahl A, Stemmler MB, Herz AV, Roth A (2012) Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. J Neurosci Methods 210:22-34 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex U1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I Na,p; I Na,t; I K; I M; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Parameter Fitting; Simplified Models; Active Dendrites; Detailed Neuronal Models; Action Potentials; Methods; Calcium dynamics;
Implementer(s): Bahl, Armin [bahl at neuro.mpg.de];
Search NeuronDB for information about:  Neocortex U1 L5B pyramidal pyramidal tract GLU cell; I Na,p; I Na,t; I K; I M; I h; I K,Ca; I Calcium; I A, slow;
load_file("stdrun.hoc")
load_file("../reduced_model.hoc")

forall e_pas = -80.495767
Rm_axosomatic = 20513.848207
forsec axosomatic_list cm = 2.411070
spinefactor = 0.691767
soma gbar_nat = 238.879842
soma gbar_kfast = 59.256783
soma gbar_kslow = 433.798677
soma gbar_nap = 1.479049
soma gbar_km = 11.118662
basal gbar_ih = 10.720289
tuft gbar_ih = 17.796075
tuft gbar_nat = 29.006481
decay_kfast = 55.581656
decay_kslow = 88.716317
hillock gbar_nat = 8302.875131
iseg gbar_nat = 17623.525167
iseg vshift2_nat = -9.567698

Ra_apical = 4.44130503e+02
apical Ra = Ra_apical
tuft gbar_sca = 2.12343632e+00
tuft vshift_sca = 8.34639038e+00
tuft gbar_kca = 8.22978203e+00

recalculate_passive_properties()
recalculate_channel_densities()