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BCM-like synaptic plasticity with conductance-based models (Narayanan Johnston, 2010)
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" ... Although the BCM-like plasticity framework has been a useful formulation to understand synaptic plasticity and metaplasticity, a mechanism for the activity-dependent regulation of this modification threshold has remained an open question. In this simulation study based on CA1 pyramidal cells, we use a modification of the calcium-dependent hypothesis proposed elsewhere and show that a change in the hyperpolarization-activated, nonspecific-cation h current is capable of shifting the modification threshold. ..."
Narayanan R, Johnston D (2010) The h current is a candidate mechanism for regulating the sliding modification threshold in a BCM-like synaptic learning rule.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal GLU cell;
Narayanan, Rishikesh [rishi at iisc.ac.in];
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Hippocampus CA1 pyramidal GLU cell
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