Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)

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Accession:147867
These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
Reference:
1 . Narayanan R, Chattarji S (2010) Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus. J Neurophysiol 103:3070-83 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Conductance distributions;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; AMPA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP; Glutamate;
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201.153968	2.213192	38.142191
216.006996	1.902304	43.246708
230.860024	1.676271	46.904669
245.713052	1.502856	49.624199
260.566080	1.364752	51.656286
275.419108	1.251713	53.192177
290.272137	1.157228	54.376758
297.698651	1.115485	54.860089
145.246761	3.721860	9.901993
157.981327	3.329345	11.001018
170.715892	3.131646	11.354636
170.715892	3.131646	11.354636
178.614060	3.064808	12.195822
186.512227	3.002975	12.974025
186.512227	3.002975	12.974025
193.356978	2.959297	13.740716
207.046478	2.836720	15.914928
220.735978	2.726047	17.998435
227.580728	2.676166	19.014760
227.580728	2.676166	19.014760
237.558144	2.596179	20.834916
257.512977	2.450785	24.269871
277.467810	2.322030	27.364686
297.422643	2.118925	32.238253
317.377476	1.942901	36.379854
337.332309	1.796143	39.673437
357.287142	1.671619	42.293334
367.264559	1.616012	43.385147
227.580728	2.676166	19.014760
232.749031	2.636869	19.808033
243.085637	2.562510	21.347235
253.422244	2.493246	22.829852
258.590547	2.460211	23.550636
258.590547	2.460211	23.550636
266.219682	2.360925	25.705416
281.477952	2.187166	29.683662
296.736222	2.039750	33.105583
311.994492	1.756656	39.494663
327.252762	1.530046	44.374205
342.511032	1.360454	47.832912
357.769302	1.227739	50.346343
373.027572	1.120503	52.209749
388.285843	1.031744	53.626962
395.914978	0.992738	54.202568
258.590547	2.460211	23.550636
268.114675	2.385701	25.178710
287.162932	2.183407	29.772995
306.211188	2.007640	33.896761
325.259445	1.859999	37.357753
344.307702	1.733635	40.229000
363.355958	1.624004	42.579263
382.404215	1.527922	44.494774
391.928343	1.484078	45.304447
186.512227	3.002975	12.974025
193.042628	2.610885	21.066029
206.103430	2.108177	30.222404
219.164231	1.804292	34.707998
232.225033	1.607830	36.938670
245.285834	1.476730	37.759122
258.346635	1.387958	37.579514
271.407437	1.327333	38.011183
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277.937838	1.303788	39.250910
286.972368	1.274891	39.940913
305.041430	1.218717	41.331669
323.110491	1.165361	42.732314
341.179552	1.114762	44.081955
359.248613	1.066902	45.328750
377.317674	1.021764	46.444932
395.386736	0.979295	47.432424
404.421266	0.958884	47.870034
277.937838	1.303788	39.250910
286.572899	1.271543	39.934483
303.843022	1.230591	40.889991
321.113145	1.190402	41.896499
338.383268	1.150808	42.921499
355.653391	1.111746	43.936452
372.923514	1.073260	44.917721
390.193637	1.035483	45.844453
407.463760	0.998601	46.699029
424.733883	0.962806	47.471725
442.004006	0.928259	48.164536
459.274129	0.895070	48.792443
467.909191	0.878875	49.075389
170.715892	3.131646	11.354636
182.162280	2.882572	13.136693
193.608667	2.707706	14.233799
193.608667	2.707706	14.233799
198.149760	2.645033	14.737718
207.231944	2.530651	15.602300
216.314129	2.429802	16.278340
220.855221	2.384030	16.550039
220.855221	2.384030	16.550039
230.861703	2.246086	20.196065
250.874666	2.027945	25.645658
270.887629	1.861450	29.462619
290.900592	1.727936	32.402263
310.913555	1.616497	34.915760
330.926518	1.520371	37.260788
350.939481	1.435234	39.514412
370.952444	1.358317	41.638379
390.965407	1.287892	43.559902
410.978370	1.222928	45.215817
430.991333	1.162819	46.577784
451.004296	1.107171	47.671334
471.017259	1.055662	48.560978
481.023740	1.031213	48.934210
220.855221	2.384030	16.550039
229.617677	2.298513	17.441193
247.142588	2.152342	18.786802
264.667499	2.035464	19.590911
282.192410	1.943379	19.947172
299.717321	1.871939	20.014712
308.479777	1.842637	20.008833
308.479777	1.842637	20.008833
315.491861	1.818106	20.102004
322.503946	1.795542	20.168926
322.503946	1.795542	20.168926
329.485878	1.623954	26.159328
343.449742	1.380203	34.560085
357.413606	1.212485	39.608530
371.377470	1.087542	43.101946
385.341335	0.989315	45.815317
399.305199	0.909060	48.099583
413.269063	0.841620	50.086273
427.232927	0.783769	51.797050
441.196791	0.733382	53.218766
455.160655	0.688989	54.350151
469.124519	0.649518	55.221657
483.088384	0.614157	55.891516
497.052248	0.582271	56.418315
504.034180	0.567417	56.632447
322.503946	1.795542	20.168926
329.017450	1.773853	20.344072
342.044458	1.735037	20.633648
355.071466	1.710913	20.795885
361.584970	1.701184	20.854780
361.584970	1.701184	20.854780
370.668828	1.630839	22.971394
388.836544	1.512619	26.735255
407.004260	1.417270	29.649298
425.171976	1.338086	31.909353
443.339692	1.270575	33.743772
461.507408	1.211607	35.331457
479.675124	1.158938	36.808016
497.842840	1.110927	38.266647
516.010556	1.066370	39.742605
534.178272	1.024405	41.220839
552.345988	0.984443	42.659624
570.513704	0.946127	44.010084
588.681420	0.909281	45.230646
597.765278	0.891210	45.764366
597.765278	0.891210	45.764366
604.048722	0.853355	46.412284
616.615610	0.786458	47.931059
629.182499	0.729726	49.611591
635.465943	0.704422	50.420847
597.765278	0.891210	45.764366
604.318782	0.870354	46.264661
617.425790	0.803895	47.926715
630.532798	0.746734	49.528800
643.639805	0.697182	51.001037
656.746813	0.653805	52.292127
669.853821	0.615493	53.384353
682.960829	0.581384	54.298473
689.514333	0.565638	54.690476
361.584970	1.701184	20.854780
370.625454	1.677019	21.331632
388.706423	1.623227	22.398616
406.787392	1.576277	23.316293
424.868361	1.534954	24.112661
442.949330	1.498205	24.880658
461.030299	1.465092	25.742001
479.111268	1.434740	26.771655
488.151752	1.420096	27.349211
488.151752	1.420096	27.349211
497.371511	1.372699	28.460987
515.811027	1.287657	30.911911
534.250543	1.213714	33.443188
552.690060	1.148110	35.893051
571.129576	1.088877	38.211704
589.569093	1.034673	40.370855
608.008609	0.984620	42.332879
626.448125	0.938166	44.058694
644.887642	0.894960	45.527770
663.327158	0.854754	46.751584
681.766675	0.817338	47.773191
690.986433	0.799495	48.209865
488.151752	1.420096	27.349211
500.255799	1.389954	28.325550
524.463892	1.331386	30.335699
548.671984	1.275632	32.375227
572.880077	1.222221	34.360630
597.088170	1.170975	36.220245
621.296263	1.121936	37.905418
645.504356	1.075242	39.403876
657.608402	1.052585	40.072414
308.479777	1.842637	20.008833
317.544488	1.755980	22.970375
335.673909	1.608702	28.164042
353.803331	1.487517	32.446800
371.932753	1.385001	36.027538
390.062175	1.296512	39.026734
399.126885	1.256375	40.312030
399.126885	1.256375	40.312030
405.508434	1.183898	42.425285
418.271530	1.063752	45.881437
431.034627	0.968231	48.499729
437.416175	0.927286	49.552798
399.126885	1.256375	40.312030
406.261917	1.206020	41.795934
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434.802043	0.961924	48.670854
441.937074	0.917079	49.814382
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198.948866	2.657278	15.502301
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220.309660	2.477898	20.028732
225.649858	2.437779	21.026404
225.649858	2.437779	21.026404
232.654702	2.188121	27.237643
246.664388	1.841259	35.060808
260.674075	1.608035	39.700620
274.683761	1.437381	42.846032
288.693448	1.305055	45.221803
302.703134	1.197999	47.197532
316.712821	1.108575	48.969367
330.722507	1.032061	50.609907
344.732194	0.965414	52.105930
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372.751567	0.854190	54.494875
386.761254	0.807154	55.340806
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414.780627	0.726151	56.465254
428.790313	0.691020	56.850820
435.795157	0.674542	57.008842
225.649858	2.437779	21.026404
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246.583225	2.223269	26.936137
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105.401244	4.359876	10.252543
124.707487	4.026063	12.908907
144.013730	3.742396	15.048855
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172.973094	3.373507	17.633271
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296.307571	1.619344	37.857335
302.545164	1.544162	39.329293
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358.683498	1.125598	47.008298
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358.683498	1.125598	47.008298
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379.422169	1.029622	48.710587
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517.679979	0.634475	56.839076
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538.418650	0.595558	57.228755
296.307571	1.619344	37.857335
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336.617755	1.267388	45.154255
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355.842798	1.125317	48.104787
368.659493	1.047227	49.865650
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336.617755	1.267388	45.154255
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396.714175	0.925186	52.414901
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253.320159	2.067426	29.020242
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318.064689	1.667081	32.782788
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456.802968	1.375611	35.900693
456.802968	1.375611	35.900693
464.543378	1.347735	36.354975
480.024197	1.294424	37.330675
495.505016	1.244781	38.375804
510.985836	1.188218	39.684331
526.466655	1.082576	42.379947
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603.870752	0.759756	51.089854
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712.236489	0.521392	56.996705
719.976898	0.508930	57.144227
456.802968	1.375611	35.900693
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482.252654	1.285520	37.750906
499.219111	1.230546	39.022387
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567.084939	0.889239	48.386144
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601.017853	0.760283	52.334015
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634.950767	0.662073	54.932152
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668.883681	0.584464	56.399068
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440.751393	0.706987	56.731811
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150.743933	4.089328	7.954628
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162.163107	3.617683	12.936077
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225.748096	2.522480	28.125419
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290.283324	1.997551	37.642766
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432.765139	0.961014	55.310631
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276.764089	1.775741	41.685601
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320.492084	1.327832	49.475565
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349.644080	1.140733	52.881934
364.220078	1.065661	54.115705
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415.236072	0.865100	56.581463
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165.314961	3.528154	14.406862
172.236077	3.097604	23.474522
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227.605006	1.682233	48.185103
241.447238	1.523707	50.433184
255.289470	1.395098	52.148234
262.210587	1.339346	52.853668
165.314961	3.528154	14.406862
166.797360	3.487902	15.094169
168.279758	3.448979	15.756429
168.279758	3.448979	15.756429
176.339033	2.978460	24.490155
192.457581	2.399452	33.728182
208.576129	2.046214	38.638960
224.694678	1.799297	42.658271
240.813226	1.688915	44.934703
256.931775	1.623123	46.327160
273.050323	1.561190	47.555130
289.168872	1.502774	48.577133
305.287420	1.447646	49.384644
321.405969	1.395622	50.003566
337.524517	1.346535	50.485161
345.583791	1.322943	50.677333
168.279758	3.448979	15.756429
175.903455	3.268069	19.364993
191.150848	2.651866	30.604445
206.398241	2.215602	37.496006
221.645634	1.922929	41.731623
236.893027	1.708574	44.774524
252.140420	1.542053	47.262074
267.387813	1.407227	49.466858
282.635206	1.294810	51.428443
297.882599	1.199097	53.091115
313.129992	1.136230	54.082733
328.377385	1.075547	54.844578
343.624778	1.007594	55.565480
358.872172	0.947549	56.129204
366.495868	0.920010	56.359930
150.743933	4.089328	7.954628
165.410608	3.912419	8.992782
180.077283	3.756215	9.916162
180.077283	3.756215	9.916162
185.081139	3.597463	12.494577
195.088850	3.333751	16.816214
205.096561	3.123325	20.090102
210.100416	3.032867	21.454256
210.100416	3.032867	21.454256
217.867323	2.684242	28.712722
233.401136	2.207232	37.803079
248.934949	1.890529	43.396049
264.468762	1.661475	47.234670
280.002576	1.486498	49.973942
295.536389	1.347662	51.978145
311.070202	1.234386	53.490815
318.837108	1.185083	54.100903
210.100416	3.032867	21.454256
217.374627	2.911129	23.429639
231.923048	2.704908	26.651260
246.471469	2.535453	29.266258
261.019890	2.391930	31.618047
275.568311	2.267114	33.895791
282.842522	2.209883	35.015918
282.842522	2.209883	35.015918
289.293891	2.064891	37.358158
302.196629	1.830037	41.466153
315.099368	1.647710	44.804568
328.002107	1.501161	47.494639
340.904845	1.380249	49.654698
353.807584	1.278461	51.374229
366.710322	1.191397	52.737621
379.613061	1.115952	53.827753
392.515800	1.049872	54.713272
398.967169	1.019750	55.087314
282.842522	2.209883	35.015918
293.219840	2.125582	36.635898
313.974476	1.974041	39.528022
334.729112	1.842200	41.993045
355.483748	1.726415	44.041986
376.238384	1.624039	45.725720
386.615702	1.577041	46.436289
180.077283	3.756215	9.916162
194.885379	3.574991	11.473844
209.693474	3.416106	12.840008
209.693474	3.416106	12.840008
210.138657	3.411655	12.883993
210.583841	3.407221	12.927806
210.583841	3.407221	12.927806
218.392933	2.937215	22.696677
234.011118	2.353116	33.563618
249.629302	1.995303	39.322134
265.247487	1.747586	43.032168
280.865671	1.562360	45.788218
296.483856	1.416325	48.086006
312.102041	1.296785	50.124606
327.720225	1.196291	51.926825
343.338410	1.110197	53.445871
358.956594	1.035425	54.645198
374.574779	0.969802	55.538688
390.192963	0.911713	56.194630
405.811148	0.859916	56.691961
413.620240	0.835998	56.888760
210.583841	3.407221	12.927806
214.665383	3.367714	13.372762
218.746924	3.329449	13.804202
218.746924	3.329449	13.804202
222.345216	3.102284	19.086788
229.541799	2.741626	27.450908
236.738382	2.467650	33.262926
240.336674	2.353445	35.559156
218.746924	3.329449	13.804202
230.193057	3.228477	14.943510
241.639190	3.135556	15.978892
241.639190	3.135556	15.978892
249.216383	2.745060	24.340414
264.370769	2.238002	34.148958
279.525154	1.916022	39.578742
294.679540	1.688305	43.166190
309.833926	1.515650	45.880590
324.988311	1.378250	48.159383
340.142697	1.265058	50.174650
355.297082	1.169473	51.942954
370.451468	1.087307	53.426324
385.605854	1.015749	54.598434
400.760239	0.952794	55.478922
415.914625	0.896943	56.133144
431.069010	0.847040	56.634664
438.646203	0.823964	56.834575
241.639190	3.135556	15.978892
244.019097	3.117073	16.217373
246.399003	3.098855	16.451500
246.399003	3.098855	16.451500
253.683273	2.732629	24.484142
268.251814	2.243634	34.250457
282.820356	1.925136	39.919125
297.388897	1.696379	43.841393
311.957438	1.521526	46.877514
326.525979	1.382093	49.353582
341.094520	1.267521	51.369892
355.663061	1.171293	52.965198
370.231602	1.089110	54.192512
384.800143	1.017978	55.130570
399.368684	0.955738	55.859475
406.652955	0.927374	56.153862
246.399003	3.098855	16.451500
254.644150	3.009313	17.738320
271.134444	2.827362	20.327150
287.624739	2.616241	23.194052
304.115033	2.380938	26.099899
320.605327	2.200262	28.050495
337.095622	2.059962	29.375080
353.585916	1.950100	30.342393
361.831063	1.903940	30.751994
361.831063	1.903940	30.751994
369.701788	1.845088	31.998722
385.443237	1.739321	34.236231
401.184687	1.544699	38.295877
416.926136	1.376284	41.529719
432.667586	1.251927	43.623513
448.409035	1.155976	45.023937
464.150485	1.079150	45.991242
479.891934	1.015489	46.731144
495.633383	0.960886	47.528811
511.374833	0.912327	48.730171
527.116282	0.867486	50.366496
534.987007	0.845674	51.257897
534.987007	0.845674	51.257897
541.999322	0.819555	51.525879
556.023953	0.770729	52.126372
570.048583	0.726574	52.860276
584.073213	0.686613	53.671886
598.097843	0.650360	54.470092
605.110159	0.633408	54.833377
534.987007	0.845674	51.257897
541.331590	0.825231	51.633728
554.020755	0.786001	52.321178
566.709920	0.749281	52.969475
579.399086	0.714970	53.583239
592.088251	0.682935	54.166626
604.777416	0.653031	54.720564
617.466581	0.625105	55.239627
630.155747	0.599005	55.716346
642.844912	0.574586	56.150122
649.189494	0.562912	56.344943
361.831063	1.903940	30.751994
369.906106	1.853834	31.597289
386.056193	1.764157	33.087974
402.206280	1.686328	34.380078
418.356366	1.617651	35.525655
434.506453	1.556062	36.573377
442.581496	1.527176	37.065812
442.581496	1.527176	37.065812
450.658503	1.456153	38.568977
466.812517	1.295198	42.176139
482.966531	1.170459	45.066580
499.120545	1.069544	47.482534
515.274559	0.985208	49.600424
531.428573	0.913044	51.462950
547.582587	0.850265	53.045249
563.736601	0.795013	54.315472
579.890614	0.745967	55.280974
596.044628	0.702124	56.000319
612.198642	0.662693	56.551154
620.275649	0.644347	56.770105
442.581496	1.527176	37.065812
449.497501	1.444766	38.789821
463.329512	1.307472	41.850106
477.161522	1.197450	44.366831
490.993533	1.106339	46.492753
504.825543	1.028885	48.375111
518.657553	0.961689	50.080384
532.489564	0.902494	51.614381
546.321574	0.849763	52.954116
560.153585	0.802404	54.075365
573.985595	0.759607	54.972224
587.817605	0.720735	55.669006
601.649616	0.685269	56.212122
615.481626	0.652784	56.648436
622.397632	0.637485	56.828632
209.693474	3.416106	12.840008
217.502558	3.344419	14.301302
233.120727	3.100505	19.395180
248.738895	2.682568	27.742032
264.357064	2.484196	31.470049
279.975233	2.316923	34.487622
295.593401	2.065317	38.833536
311.211570	1.790016	43.470575
326.829738	1.586079	46.926900
342.447907	1.427243	49.627878
358.066075	1.299173	51.724914
373.684244	1.193277	53.311999
389.302412	1.104018	54.506523
404.920581	1.027627	55.419712
412.729665	0.993329	55.784521