Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)

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Accession:147867
These simulations examined the atrophy induced changes in electrophysiological properties of CA3 pyramidal neurons. We found these neurons change from bursting to regular spiking as atrophy increases. Region-specific atrophy induced region-specific increases in synaptic excitability in a passive dendritic tree. All dendritic compartments of an atrophied neuron had greater synaptic excitability and a larger voltage transfer to the soma than the control neuron.
Reference:
1 . Narayanan R, Chattarji S (2010) Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus. J Neurophysiol 103:3070-83 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Conductance distributions;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; AMPA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I_AHP; Glutamate;
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172.973094	4.156632	17.694444
181.782699	3.905677	20.888539
199.401910	3.504404	25.808432
217.021122	3.197879	29.348482
234.640333	2.955849	31.982304
252.259544	2.759781	33.967587
269.878755	2.555210	35.830193
287.497966	2.245439	38.207670
296.307571	2.133527	39.075198
296.307571	2.133527	39.075198
304.219294	2.016273	40.664073
320.042740	1.824441	43.265875
335.866186	1.673548	45.237495
351.689632	1.550221	46.799744
367.513078	1.446068	48.143297
383.336524	1.355646	49.411802
399.159970	1.275365	50.687187
414.983416	1.202863	51.966932
430.806862	1.136618	53.192235
446.630308	1.075668	54.291201
462.453754	1.019393	55.205567
478.277200	0.967351	55.910792
494.100646	0.919177	56.427622
509.924092	0.874529	56.813002
525.747538	0.833094	57.124491
533.659261	0.813384	57.253604
296.307571	2.133527	39.075198
303.025935	2.030816	40.597271
316.462663	1.856142	43.293356
329.899391	1.711914	45.741215
336.617755	1.647969	46.889859
336.617755	1.647969	46.889859
342.563056	1.585090	47.723578
354.453658	1.473008	49.351371
366.344261	1.376469	50.847608
372.289562	1.332953	51.512648
336.617755	1.647969	46.889859
344.618016	1.575328	48.040367
360.618539	1.447106	50.081530
376.619062	1.337799	51.819368
392.619585	1.243317	53.240862
408.620108	1.160757	54.362080
424.620631	1.087958	55.235256
440.621154	1.023265	55.927330
448.621415	0.993424	56.210499
172.973094	4.156632	17.694444
181.007800	3.981038	19.433306
197.077213	3.557208	23.377513
213.146627	3.234911	25.993377
229.216040	2.986379	27.685648
245.285453	2.792840	28.768469
253.320159	2.712199	29.159210
253.320159	2.712199	29.159210
262.569378	2.618562	29.967563
281.067815	2.460643	31.213910
299.566252	2.334860	32.120649
318.064689	2.233617	32.847091
336.563126	2.180270	33.247292
355.061564	2.132096	33.602966
373.560001	2.093415	33.875298
392.058438	2.055940	34.125189
410.556875	1.999457	34.536953
429.055312	1.936741	35.201879
447.553749	1.879984	36.097484
456.802968	1.852624	36.620961
456.802968	1.852624	36.620961
464.420390	1.817024	36.974746
479.655235	1.748477	37.762776
494.890080	1.684173	38.653077
510.124924	1.613367	39.776927
525.359769	1.475723	42.308695
540.594614	1.359543	44.550032
555.829459	1.262534	46.409950
571.064303	1.179277	48.052174
586.299148	1.106191	49.594715
601.533993	1.040907	51.071161
616.768837	0.981858	52.452671
632.003682	0.928012	53.686476
647.238527	0.878664	54.723064
662.473372	0.833301	55.537385
677.708216	0.791506	56.147481
692.943061	0.752917	56.606409
708.177906	0.717210	56.971365
715.795328	0.700257	57.120809
456.802968	1.852624	36.620961
464.735118	1.812220	37.242935
480.599419	1.734593	38.517310
496.463719	1.661891	39.821128
512.328020	1.593747	41.109979
528.192320	1.472769	43.560424
544.056621	1.332378	46.658170
559.920922	1.217387	49.244816
575.785222	1.121039	51.323303
591.649523	1.038890	52.938779
607.513823	0.967866	54.179040
623.378124	0.905754	55.144461
631.310274	0.877393	55.535883
253.320159	2.712199	29.159210
260.815878	2.486703	33.218128
275.807315	2.148759	39.029130
290.798752	1.904355	42.975946
305.790189	1.716233	45.986071
320.781626	1.565002	48.475216
335.773064	1.439609	50.582245
350.764501	1.333300	52.330673
365.755938	1.241692	53.722248
380.747375	1.161761	54.788149
395.738812	1.091312	55.597247
410.730249	1.028694	56.223489
418.225968	0.999818	56.474520
61.003702	5.870408	6.108810
75.960407	5.788797	6.290632
105.873817	5.542262	7.093264
135.787228	5.311822	8.161286
150.743933	5.196884	8.772959
150.743933	5.196884	8.772959
156.453520	4.967592	11.712144
162.163107	4.765277	14.462642
162.163107	4.765277	14.462642
172.760605	4.436574	18.966409
193.955602	3.926502	25.727383
215.150598	3.540608	31.015549
225.748096	3.377651	33.360404
225.748096	3.377651	33.360404
233.101624	3.269777	34.806368
247.808680	3.074357	37.390440
262.515736	2.902354	39.622419
277.222792	2.749714	41.541880
291.929848	2.613333	43.190023
299.283376	2.550355	43.918720
225.748096	3.377651	33.360404
233.664187	3.260487	34.878984
249.496369	3.045903	37.633790
265.328550	2.627584	42.999065
281.160732	2.295936	47.056226
296.992914	2.045881	49.871403
304.909005	1.942172	50.957236
162.163107	4.765277	14.462642
163.739034	4.711305	15.305938
165.314961	4.658766	16.131087
165.314961	4.658766	16.131087
172.101629	4.115383	24.808920
185.674966	3.375062	35.540397
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206.034971	2.699534	44.018267
165.314961	4.658766	16.131087
166.797360	4.610368	16.890923
168.279758	4.563137	17.633353
168.279758	4.563137	17.633353
173.660164	4.140838	24.302733
184.420974	3.520247	33.405439
195.181785	3.082169	39.218376
205.942595	2.753355	43.247493
216.703406	2.495872	46.203664
222.083811	2.386670	47.396776
168.279758	4.563137	17.633353
175.477539	4.347849	21.032137
189.873102	3.596870	32.232401
204.268664	3.013203	39.973950
218.664226	2.611064	44.805289
233.059788	2.314246	48.091063
240.257569	2.192637	49.360392
150.743933	5.196884	8.772959
165.410608	5.037455	9.843532
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180.077283	4.888983	10.896964
190.353807	4.535273	16.337056
210.906855	3.984173	24.796835
231.459902	3.569748	30.886237
252.012950	3.242690	35.550673
272.565998	2.976011	39.184437
282.842522	2.859781	40.672665
282.842522	2.859781	40.672665
285.967387	2.769286	41.786115
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282.842522	2.859781	40.672665
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209.693474	4.516277	13.836945
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210.583841	4.506060	13.921572
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274.418072	2.165691	47.582536
288.603457	1.962903	50.022772
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331.159612	1.542880	54.408066
338.252304	1.490698	54.866918
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226.111516	4.334917	15.445868
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241.639190	4.181130	16.842739
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280.364635	2.564509	40.400610
295.854812	2.255972	44.225884
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326.835168	1.833578	49.660416
342.325345	1.679668	51.685211
357.815523	1.550341	53.290385
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388.795879	1.344182	55.422429
404.286056	1.260464	56.117842
412.031145	1.222296	56.393565
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244.019097	4.158355	17.075837
246.399003	4.135872	17.306441
246.399003	4.135872	17.306441
252.543007	3.720473	24.363669
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313.983045	1.989352	49.479636
326.271053	1.833762	51.220388
332.415056	1.765639	51.948259
246.399003	4.135872	17.306441
254.644150	4.025366	18.471130
271.134444	3.800262	20.864418
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361.831063	2.654423	31.026730
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385.443237	2.433516	34.492219
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511.374833	1.226148	52.036274
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534.987007	1.121823	53.892359
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536.011820	1.116801	53.897495
534.987007	1.121823	53.892359
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553.850835	1.048394	55.088392
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616.730259	0.851214	57.092788
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442.581496	2.134701	37.724015
442.581496	2.134701	37.724015
449.394342	2.055504	38.905337
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476.645724	1.694640	44.922875
490.271416	1.561280	47.302723
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517.522798	1.350542	51.107420
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572.025563	1.062126	55.439120
585.651255	1.007655	56.038461
592.464100	0.982267	56.286996
442.581496	2.134701	37.724015
449.944833	2.013916	39.464613
464.671506	1.813102	42.658485
479.398179	1.652590	45.366376
494.124853	1.519994	47.687172
508.851526	1.407645	49.713191
523.578199	1.310647	51.470503
538.304872	1.225744	52.948463
553.031546	1.150669	54.138682
567.758219	1.083749	55.063332
582.484892	1.023694	55.776919
597.211566	0.969483	56.340105
604.574902	0.944210	56.569224
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218.189451	4.415811	15.396782
235.181404	4.046209	21.447418
252.173357	3.500292	30.183703
269.165309	3.225402	34.340366
286.157262	2.970811	37.989304
303.149215	2.541059	43.722487
320.141168	2.200742	47.853984
328.637145	2.066240	49.366852