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State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
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A Markov model of sodium channels was developed that includes drug binding to fast inactivated states. This was incorporated into a model of the dentate gyrus to investigate the effects of anti-epileptic drugs on neuron and network properties.
Thomas EA, Petrou S (2013) Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin.
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Neuron or other electrically excitable cell;
Dentate gyrus granule GLU cell;
Dentate gyrus mossy cell;
Dentate gyrus basket cell;
Dentate gyrus hilar cell;
Ion Channel Kinetics;
Thomas, Evan [evan at evan-thomas.net];
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Dentate gyrus granule GLU cell
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