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State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
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Model Information
Model File
Accession:
149174
A Markov model of sodium channels was developed that includes drug binding to fast inactivated states. This was incorporated into a model of the dentate gyrus to investigate the effects of anti-epileptic drugs on neuron and network properties.
Reference:
1 .
Thomas EA, Petrou S (2013) Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin.
Epilepsia
54
:1195-202
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Neuron or other electrically excitable cell;
Axon;
Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Dentate gyrus granule GLU cell;
Dentate gyrus mossy cell;
Dentate gyrus basket cell;
Dentate gyrus hilar cell;
Channel(s):
I Na,t;
I A;
I_AHP;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
MATLAB;
Model Concept(s):
Ion Channel Kinetics;
Epilepsy;
Calcium dynamics;
Drug binding;
Markov-type model;
Implementer(s):
Thomas, Evan [evan at evan-thomas.net];
Search NeuronDB
for information about:
Dentate gyrus granule GLU cell
;
GabaA
;
AMPA
;
I Na,t
;
I A
;
I_AHP
;
Gaba
;
Glutamate
;
/
ThomasPetrou2013
Fig 4
Data
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Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
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Dentate gyrus network model (Tejada et al 2014)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
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Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Encoding and retrieval in a model of the hippocampal CA1 microcircuit (Cutsuridis et al. 2009)
Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
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CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
Cell splitting in neural networks extends strong scaling (Hines et al. 2008)
Dentate gyrus network model (Santhakumar et al 2005)
Dentate gyrus network model (Tejada et al 2014)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
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Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
Parallel network simulations with NEURON (Migliore et al 2006)
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Dentate gyrus network model (Santhakumar et al 2005)
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apchew.m
async.hoc
runall.py
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