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Roles of essential kinases in induction of late hippocampal LTP (Smolen et al., 2006)
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"… Convergence of multiple kinase activities to induce L-LTP helps to generate a threshold whereby the amount of L-LTP varies steeply with the number of brief (tetanic) electrical stimuli. The model simulates tetanic, -burst, pairing-induced, and chemical L-LTP, as well as L-LTP due to synaptic tagging. The model also simulates inhibition of L-LTP by inhibition of MAPK, CAMKII, PKA, or CAMKIV. The model predicts results of experiments to delineate mechanisms underlying L-LTP induction and expression. …"
Smolen P, Baxter DA, Byrne JH (2006) A model of the roles of essential kinases in the induction and expression of late long-term potentiation.
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Hippocampus CA1 pyramidal GLU cell;
Long-term Synaptic Plasticity;
Byrne, John [john.h.byrne at uth.tmc.edu];
Smolen, Paul [paul.d.smolen at uth.tmc.edu];
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Hippocampus CA1 pyramidal GLU cell
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