Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)

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Accession:150551
A morphologically realistic, conductance-based model equipped with kinetic schemes that govern several calcium signalling modules and pathways in CA1 pyramidal neurons
Reference:
1 . Ashhad S, Narayanan R (2013) Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity. J Physiol 591:1645-69 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; mGluR; IP3;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Synaptic Plasticity; Signaling pathways; Calcium dynamics; G-protein coupled; Calcium waves;
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]; Ashhad, Sufyan [soofy at mbu.iisc.ernet.in];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; NMDA; mGluR; IP3; I Na,t; I L high threshold; I T low threshold; I A; I K; Ca pump; Glutamate;
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AshhadNarayanan2013
Readme.html
cal4.mod
Calamp.mod
caltype.mod
camax.mod
cat.mod
ghknmda.mod
ip3dif.mod
kadist.mod *
kaprox.mod *
kdrca1.mod
mglur.mod
na3.mod
nax.mod *
Wghkampa.mod
CalciumWave.hoc
distance.hoc
Fig4F-G.hoc
Fig6C-F.hoc
mosinit.hoc
n123.hoc
n123_all.dis
n123_all.rdis
ObliquePath.hoc
oblique-paths.hoc
parameters.hoc
screenshot4F.png
screenshot4G.png
screenshot6C-F.png
                            
load_file("nrngui.hoc")
load_file("CalciumWave.hoc")



/**********************************************************************/




objectvar g[20]         // max 20 graphs
ngraph = 0

proc addgraph() {  // define subroutine to add a new graph
                // addgraph("variable", minvalue, maxvalue)
    ngraph = ngraph+1
    ii = ngraph-1
    g[ii] = new Graph()
    g[ii].size(0,tstop,$2,$3)
    g[ii].xaxis()
    g[ii].yaxis()
    g[ii].addvar($s1,1,0)
    g[ii].save_name("graphList[0].")
    graphList[0].append(g[ii])
}

if(ismenu==0) {
  nrnmainmenu()         // create main menu
  nrncontrolmenu()      // create control menu
  ismenu=1


addgraph("soma[1].cai (0.5)",50e-6,1.4e-3)
g[ii].addexpr("apical[0].cai (0.5)",2,1)
g[ii].addexpr("apical[14].cai (0.5)",3,1)
g[ii].addexpr("apical[16].cai (0.5)",4,1)
g[ii].addexpr("apical[46].cai (0.5)",5,1)
g[ii].addexpr("apical[1].cai (0.1)",6,1)
g[ii].addexpr("apical[1].cai (0.5)",7,1)
g[ii].addexpr("apical[112].cai (0.3)",8,1)

}
 //Make shape plot for [Ca2+]c
objref shbox, sl, s

proc make_shapeplot() {
        shbox = new VBox()
        shbox.intercept(1)
        sl = new SectionList()
        sl.wholetree()
        s = new PlotShape(sl)
        s.colormap(13,1)

        s.colormap(0,78,161,215)
        s.colormap(1,116,203,218)
        s.colormap(2,112,190,109)
        s.colormap(3,146,198,71)
        //s.colormap(4,207,219,59)
        s.colormap(4,227,152,37)
        s.colormap(5,243,140,47)
        s.colormap(6,239,112,45)
        s.colormap(7,235,82,44)
        s.colormap(8,218,48,52)
        s.colormap(9,202,32,67)
        s.colormap(10,170,33,98)
        s.colormap(11,136,41,125)
        s.colormap(12,107,39,109)

       s.variable("cai")
//s.variable("gcalbar_call")
        s.exec_menu("Shape Plot")
        s.scale(5e-5,3e-4) 
//s.scale(5e-5 5e-4e-) 
        fast_flush_list.append(s)
        shbox.intercept(0)
        s.show(0)
        shbox.map("Shape",600,400,400,400)
}

// Make shape plot for Ca2+  wave amplitude 
objref shbox1, sl1, s1

proc make_shapeplot1() {
        shbox1 = new VBox()
        shbox1.intercept(1)
        sl1 = new SectionList()
        sl1.wholetree()
        s1 = new PlotShape(sl1)
        s1.colormap(13,1)

        s1.colormap(0,78,161,215)
        s1.colormap(1,116,203,218)
        s1.colormap(2,112,190,109)
        s1.colormap(3,146,198,71)
        //s.colormap(4,207,219,59)
        s1.colormap(4,227,152,37)
        s1.colormap(5,243,140,47)
        s1.colormap(6,239,112,45)
        s1.colormap(7,235,82,44)
        s1.colormap(8,218,48,52)
        s1.colormap(9,202,32,67)
        s1.colormap(10,170,33,98)
        s1.colormap(11,136,41,125)
        s1.colormap(12,107,39,109)
        s1.variable("camx_camax")
        s1.exec_menu("Shape Plot")
        s1.scale(0.5e-3,1.7e-3) 
        fast_flush_list.append(s1)
        shbox1.intercept(0)
        s1.show(0)
        shbox1.map("Shape",1200,400,400,400)
}
//make_shapeplot()
make_shapeplot1()