Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)

 Download zip file   Auto-launch 
Help downloading and running models
A biophysical single compartment model of the dorsal lateral striatum medium spiny neuron is presented here. The model is an implementation then adaptation of a previously described model (Mahon et al. 2002). The model has been adapted to include NMDA and AMPA receptor models that have been fit to dorsal lateral striatal neurons. The receptor models allow for excitation by other neuron models.
1 . Biddell K, Johnson J (2013) A Biophysical Model of Cortical Glutamate Excitation of Medium Spiny Neurons in the Dorsal Lateral Striatum 56th IEEE Midwest Symposium on Circuits and Systems
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Connectionist Network;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum spiny neuron;
Channel(s): I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Short-term Synaptic Plasticity; Parkinson's; Learning; Deep brain stimulation; Olfaction;
Implementer(s): Biddell, Kevin [kevin.biddell at];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; AMPA; NMDA; I Na,p; I K; I K,leak; I A, slow; I_Ks; I Krp; I Na, leak; Glutamate;
//This is a MSN model as implemented by Kevin Biddell
// all questions should be directed to Kevin at

//Created by Kevin Biddell

celsius =37 //Wickens and Wilson 1998 OK
tstop = 150
create str_soma 
access str_soma
//load_file("")	//Added KMB 3/28/2012

      nseg = 3
	diam= 18	
      	L = 11	// KMB approximation of size of real striatal neuron of wickens and Wilson 1998 
	insert Nam
	insert Km
	insert Leakm
	insert Kirm
	insert KAfm
	insert KAsm
	insert Krpm
	insert NaPm
	insert NaSm
	I_stim() // ran to excite/stimulate the cell by way of current injection
	cor_stim() // ran to excite/stimulate the cell by way of cortex

//  insert postsynaptic mechansisms ie NMDA and AMPA channels developed from Wolf et al


objectvar strNMDAk
strNMDAk = new NMDAk()          // create synapse
str_soma strNMDAk.loc(0.4)         // assign postsynaptic compartment


objectvar strAMPAk
strAMPAk = new AMPAk()          // create post synapse
str_soma strAMPAk.loc(0.5)         // assign postsynaptic compartment

objref NMDAcon, AMPAcon, GluCon1,GluCon2,GluCon3,GluCon4
//direct inputs theoretically should be the same synaptic strength, frequency of input is the cause of depolarization
NMDAcon = new NetCon(stim2,strNMDAk,0.1,1,1) //connection between artificial cells & channels
AMPAcon = new NetCon(stim2,strAMPAk,0.1,1,1) //connection between artificial cells & channels
//4.14.13 KMB changed the weights of the background stimulation to 0.8 from 1
GluCon1 = new NetCon(dwnbkgrnd,strNMDAk,0.1,1,0.8)
GluCon2 = new NetCon(dwnbkgrnd,strAMPAk,0.1,1,0.8)
GluCon3 = new NetCon(upbkgrnd,strNMDAk,0.1,1,0.8)
GluCon4 = new NetCon(upbkgrnd,strAMPAk,0.1,1,0.8)
//netcon = new NetCon(source, target, threshold, delay, weight)

v_init = -79			// from Wickens and Wilson 1998