TITLE Basic sodium current
COMMENT
from "Gamma Oscillation by Synaptic Inhibition in a Hippocampal Interneuronal Network Model" (Wang and Buzsaki 1996)
Used in Role of a Striatal Slowly Inactivating Potassion Current in Shortterm Facilitation of Corticostriatal Inputs" A computer Simulation Study" (Mahon et al. 2000)
Implemented by Kevin M. Biddell kevin.biddell@gmail.com
7/11/06
NOTE: 1S=1mho Neuron wants the units in mhos not millisiemens, please note the conversion!
Phi =5 and no q10 or temp adjustment according to Bruno Delord 11/13/06
ENDCOMMENT
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
NEURON {
SUFFIX Nam
USEION na WRITE ina
RANGE gnabar, gna, minf, hinf, ah, Bh
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
ena = 55 (mV)
gnabar = 0.035 (mho/cm2) : 35mS
phi = 5 < 0, 1e9 > : from delord 11/13/06
Vam = 28 :NOT the original value from wang and Buzsaki
Kam = 1
Vbm = 53 :NOT the original value from wang and Buzsaki
Kbm = 18
Vah = 51 :NOT the original value from wang and Buzsaki
Kah = 20
Vbh = 21 :NOT the original value from wang and Buzsaki
Kbh = 1
}
STATE {
m h
}
ASSIGNED {
v (mV)
ina (mA/cm2)
celsius (degC)
minf
hinf
ah
Bh
gna
}
BREAKPOINT {
SOLVE states METHOD cnexp
gna = gnabar*m^3*h
ina = gna*(v  ena)
}
UNITSOFF
INITIAL {
rates(v)
m = minf
h= hinf
}
DERIVATIVE states { :Computes states variable m and h
rates(v) : at the current v and dt.
h'=phi*(ah*(1h)Bh*h)
}
PROCEDURE rates(v) { :Computes rate and other constants at current v.
:Call once from HOC to initialize inf at resting v.
LOCAL am, Bm
am = (0.1*(vVam)/Kam/(exp(0.1*(vVam)/Kam)1))
Bm = 4*exp((vVbm)/Kbm)
ah = 0.07*exp((vVah)/Kah)
Bh= 1/(1+exp(0.1*(vVbh)/Kbh))
minf = am/(am+Bm)
hinf = ah/(ah+Bh)
m=minf
}
UNITSON
