Striatal Output Neuron (Mahon, Deniau, Charpier, Delord 2000)

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Accession:150621
Striatal output neurons (SONs) integrate glutamatergic synaptic inputs originating from the cerebral cortex. In vivo electrophysiological data have shown that a prior depolarization of SONs induced a short-term (1 sec)increase in their membrane excitability, which facilitated the ability of corticostriatal synaptic potentials to induce firing. Here we propose, using a computational model of SONs, that the use-dependent, short-term increase in the responsiveness of SONs mainly results from the slow kinetics of a voltage-dependent, slowly inactivating potassium A-current. This mechanism confers on SONs a form of intrinsic short-term memory that optimizes the synaptic input–output relationship as a function of their past activation.
Reference:
1 . Mahon S, Deniau JM, Charpier S, Delord B (2000) Role of a striatal slowly inactivating potassium current in short-term facilitation of corticostriatal inputs: a computer simulation study. Learn Mem 7:357-62 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Abstract Wang-Buzsaki neuron;
Channel(s): I Na,p; I Na,t; I K; I_Ks; I Krp;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Short-term Synaptic Plasticity;
Implementer(s): Biddell, Kevin [kevin.biddell at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; I Na,p; I Na,t; I K; I_Ks; I Krp;
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MahonEtAl2000
README.html
KAfm.mod *
KAsm.mod *
Kirm.mod
Km.mod *
Krpm.mod *
Leakm.mod
Nam.mod *
NaPm.mod *
NaSm.mod *
figure2a.ses
figure3a.ses
Figures2B3B.xls
init.hoc
kmb.mahon.1.hoc
mosinit.hoc *
screenshot2A.png
screenshot3Aa.png
screenshot3Ab.png
                            
//This is the mahon et al 2000 model as implemented by Kevin Biddell
// all questions should be directed to Kevin at kevin.biddell@gmail.com
// 7/7/06
// this experimental paradigm is trying to replicate fig 2A
load_file("nrngui.hoc")
create soma 
celsius =37 		// the value from mahon et al 2000
access soma

soma{
      nseg = 3
	diam= 5.6419		// from gruber c_cell this gives SA=100 uM^2
      	L = 5.6419		// from gruber c_cell this gives SA=100 uM^2
	insert Nam
	insert Km
	insert Leakm
	insert Kirm
	insert KAfm
	insert KAsm
	insert Krpm
	insert NaPm
	insert NaSm
	
	  
	
}



// create an electrode in the soma that creates two current pulses (200 ms in duration) 200ms apart

objectvar stim1,stim2

stim1 = new IClamp(0.5)
stim1.del = 100
stim1.dur = 200
stim1.amp = 0.00167		//From Fig2Ab correct only for SA=100 uM

stim2 = new IClamp(0.5)
stim2.del = 500
stim2.dur = 200
stim2.amp = 0.00167		//From Fig2Ab correct only for SA=100 uM


tstop = 800

v_init = -77.4			//11/13/06

// create an "artificial" synaptic input current
//THIS IS USED INSTEAD OF THE SECOND CURRENT INJECTED PULSE

	objref Asynm
	Asynm = new AlphaSynapse(0.1)
	Asynm.onset = 2000	//this is set at 1400 to keep it from going to include make 500
	Asynm.tau   = 15  
	Asynm.gmax  = 0.0000345 // this is in mhos in the article it is 0.0345 mS
	Asynm.e     = 0

	// the background noise input only use during synaptic input
	objref mnoise
	mnoise= new NetStim(0.1)
	mnoise.interval=7
	mnoise.number=6
	mnoise.start=2000	//this is set at 1400 to keep it from going, to include make 500
	mnoise.noise=1
	
	// creating the input point
	objectvar syn
	soma syn= new ExpSyn(0) // 15 ms is the decay time
	syn.tau=15		// this tau is for each spike of voltage
	syn.e=0
	
// creating the connection between mnoise and syn
	objref bridge
	mnoise bridge = new NetCon(mnoise,syn,-77.4,0.1,0.000004) //turn up or down change weight (last variable)
	// if ths is not satisfactory maybe you could input the noise into the created alpha synapse