Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)

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Accession:151825
We used a combined experimental and numerical parameter peeling procedure was implemented to optimize a detailed ionic mechanism for the generation and propagation of dendritic spikes in neocortical L5 pyramidal neurons. Run the cc_run.hoc to get a demo for dendritic calcium spike generated by coincidence of a back-propagating AP and distal synaptic input.
Reference:
1 . Almog M, Korngreen A (2014) A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons J Neurosci 34(1):182-196
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump;
load_3dcell(CellFileName)
    track_data =0

proc init(){
            finitialize(-70)
            save_dt=dt
            dt=10
            i=0
            for i=1,38 fadvance()
            print t
            dt=save_dt
}


a_soma SomaStimSec = new SectionRef()
apic[11] DendStimSec = new SectionRef()
DendStimSec.sec {nseg=40}

func tfunk(){local Chisq,dumm
        Chisq=0
        ra  = transvec.x(0)
        rm = transvec.x(1)
        c_m = transvec.x(2)
        epas_sim  = transvec.x(3)
        gih_end  = transvec.x(4)
	gih_x2 = transvec.x(5)
        gih_alpha=transvec.x(6)
	gih_start=transvec.x(7)
	ih_q10=transvec.x(8)
	gkslow_start= transvec.x(9)
	gkslow_alpha= transvec.x(10)
	gkslow_beta=transvec.x(11)
	gka_start= transvec.x(12)
	gka_alpha= transvec.x(13)
	gka_beta= transvec.x(14)
	gna_soma = transvec.x(15)
	gna_api = transvec.x(16)
	dist_na = transvec.x(17)
	na_shift1 = transvec.x(18)
	na_shift2 = transvec.x(19)
	pcah_soma = transvec.x(20)
	pcah_api = transvec.x(21)
	dist_cah = transvec.x(22)
	cah_shift=transvec.x(23)
	cah_shifth=transvec.x(24)

	pcar_soma = transvec.x(25)
	pcar_api = transvec.x(26)
	dist_car = transvec.x(27)
        car_shift=transvec.x(28)
	car_shifth=transvec.x(29)
	car_qm=transvec.x(30)	
	
	gsk_soma=transvec.x(31)
	gsk_dend=transvec.x(32)
	dist_sk=transvec.x(33)
	gbk_soma=transvec.x(34)
	gbk_dend=transvec.x(35)
	dist_bk=transvec.x(36)		
        density()
	return Chisq
}