Ionic mechanisms of dendritic spikes (Almog and Korngreen 2014)

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Accession:151825
We used a combined experimental and numerical parameter peeling procedure was implemented to optimize a detailed ionic mechanism for the generation and propagation of dendritic spikes in neocortical L5 pyramidal neurons. Run the cc_run.hoc to get a demo for dendritic calcium spike generated by coincidence of a back-propagating AP and distal synaptic input.
Reference:
1 . Almog M, Korngreen A (2014) A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons J Neurosci 34(1):182-196
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Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,t; I A; I K; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; Ca pump;
strdef ExperimentName, CellName,CellFileName,ApicalDendSectionName


//---------------------------------------------------------------------
// data to change in each model or execution-----------------------------
//-------------------------------------------------------------------------
CellName  =  "A140612.hoc"  
ExperimentName = "A140612cont.data"  
ApicalDendSectionName = "apic"  

celsius = 34 

NP = 37                        //num of parameters 

//----------------------------------------------------------------------------

// general parameters
objref SomaStimSec,DendStimSec
Vrest = -62				// resting potential in mV
sprint(CellFileName,"cells/%s",CellName)
cm_myelin = 0.04
g_pas_node = 0.02
v_init    = -62
Ek = -100
Ena = 60
Eca = 130

// This is rough initial parameter set. IT is overwritten by parameters loaded from best.params


//passive
ra  = 68.16690
rm  = 18017.30000
c_m  = 1.43870
epas_sim  = -31.40480
//gih
gih_end= 271.90500
gih_x2= 382.51900
gih_alpha=-0.08090
gih_start= 22.51460
ih_q10=2
//kslow
gkslow_start=2.03452
gkslow_alpha=-0.00986
gkslow_beta= 127.82800
//kfast
gka_start= 20.34520
gka_alpha= -0.00297
gka_beta= 320.43100
//na
gna_soma =128.14300
gna_api = 2.69229
dist_na = 687.53800
na_shift1 =-5.56301
na_shift2 =-4.52361
na_taum_scale=1
na_tauh_scale=1

//Ca
pcah_soma=1.33e-3
pcah_api=pcah_soma
dist_cah=600
cah_qm =2
ca_qh=2
cah_shift=0
cah_shifth=0

pcar_soma=0.27e-3
pcar_api=pcar_soma
dist_car=600
car_qh=1
car_qm=1
car_shift=0
car_shifth=0

//axon parameters
gkslow_node=1500
gka_node=1000
gna_node=30000
shift_na_act_axon=7
shift_na_inact_axon=3