Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)

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Accession:153355
"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model. To do so, we evolved a population of model instances, which differed in the density of specific conductances, capable of achieving specific output activity targets given an associated input pattern. ... We found that the strengths of many conductances, including those with differing dynamics, had strong partial correlations and that these relationships appeared to be linked by their influence on heart motor neuron activity. Conductances that had positive correlations opposed one another and had the opposite effects on activity metrics when perturbed whereas conductances that had negative correlations could compensate for one another and had similar effects on activity metrics. "
Reference:
1 . Lamb DG, Calabrese RL (2013) Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation. PLoS One 8:e79267 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Leech;
Cell Type(s): Leech heart motor neuron (HE);
Channel(s): I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Temporal Pattern Generation; Detailed Neuronal Models; Parameter sensitivity; Conductance distributions;
Implementer(s): Lamb, Damon [Damon.Lamb at neurology.ufl.edu];
Search NeuronDB for information about:  I Na,p; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium; I Na, leak;
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LambCalabrese2013
lgenesis-noX
neurokit
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// coarse asymmetrical mitral cell (olf bulb) model : camit
// Control lines start with '*'. Valid control options are 
// *relative 			- relative coords.
// *absolute			- absolute coords.
// *asymmetric			- use asymmetric compartments
// *symmetric			- use symmetric compartments

// #	name	parent		x	y	z	d	ch	dens	ch	dens...
// *hsolve

*asymmetric
*absolute

*set_global	RM	4.0
*set_global	RA	0.5
*set_global	CM	0.01

soma		none		0	0	28	19	Na_mit_hh	0.3e3	K_mit_hh	0.8e3

*set_global	RM	2.0
*set_global	RA	0.5
*set_global	CM	0.01

primary_dend	soma		0	0	660	7	Na_mit_hh	60	K_mit_hh	100

*relative

glom1		primary_dend	40	40	60	1	Na_mit_hh	60	K_mit_hh	100	glu_mit_upi	246	GABA_mit_upi	357
glom2		primary_dend	-40	40	60	1	Na_mit_hh	60	K_mit_hh	100	glu_mit_upi	246	GABA_mit_upi	357
glom3		primary_dend	-40	-40	60	1	Na_mit_hh	60	K_mit_hh	100	glu_mit_upi	246	GABA_mit_upi	357
glom4		primary_dend	40	-40	60	1	Na_mit_hh	60	K_mit_hh	100	glu_mit_upi	246	GABA_mit_upi	357

second_dend1	soma		0	200	40	4.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend11	second_dend1	200	600	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend12	second_dend1	-200	600	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357



second_dend2	soma		0	-200	40	4.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend21	second_dend2	200	-600	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend22	second_dend2	-200	-600	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357


second_dend3	soma		200	0	40	4.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend31	second_dend3	600	200	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend32	second_dend3	600	-200	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357


second_dend4	soma		-200	0	40	4.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend41	second_dend4	-600	200	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357
second_dend42	second_dend4	-600	-200	60	3.0	Na_mit_hh	60	K_mit_hh	90	glu_mit_upi	246	GABA_mit_upi	357