Gq coupled signaling pathways involved in striatal synaptic plasticity (Kim et al. 2013)

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Accession:154967
Model of Gq coupled signaling pathways underlying synaptic plasticity in striatal medium spiny projection neurons. Reactions and diffusion are implemented stochastically in a dendrite with one or more diffusionally coupled spines. Simulations demonstrate that theta burst stimulation, which produces LTP, increases the ratio of PKC:2AG as compared to 20 Hz stimulation, which produces LTD.
Reference:
1 . Kim B, Hawes SL, Gillani F, Wallace LJ, Blackwell KT (2013) Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS Comput Biol 9:e1002953 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): mGluR1;
Gene(s):
Transmitter(s):
Simulation Environment: NeuroRD;
Model Concept(s): Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; mGluR1;
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KimEtAl2013
MorphLong
Robust
readme.txt
discretized-tree.swc
mglu_2ag_reac12mar20desens025.xml
mglu_2ag_reac12mar20desens025Bapta.xml
mglur_2ag_init12mar1lowrGabg.xml *
mglur_2ag_init12mar1lowrGabgBapta10.xml
mglur_morph.xml
mglur_outPIKnewCaM.xml
mglur_stim20hz-10sITI-2xCa30dhpg.xml
mglur_stimTheta2xCa30dhpg.xml
mglurMaster20hz12mar20desens025lowrG.xml
mglurMaster20hz12mar20desens025lowrG-Bapta.xml
mglurMasterTheta12mar20desens025lowrG.xml
NeuroRD2.1.1newtableNP30.jar
sample_output-fast-conc.txt
sample_output-mesh.txt
sample_output-slow-conc.txt
UchiModel12mar20desen025lowrG_100ms0dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms1dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms25dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms5dhpg20sCa12.xml
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UchiModel12mar20desen025lowrG_1s1dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s25dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s5dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s0dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s1dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s25dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s5dhpg20sCa12-3.xml
UchiStim100ms0dhpgCaRate12.xml
UchiStim100ms1dhpg20sCa12.xml
UchiStim100ms25dhpg20sCa12.xml
UchiStim100ms5dhpg20sCa12.xml
UchiStim1s0dhpgCaRate12-3.xml
UchiStim1s1dhpg20sCa12-3.xml
UchiStim1s25dhpg20sCa12-3.xml
UchiStim1s5dhpg20sCa12-3.xml
UchiStim5s0dhpgCaRate12-3-3-2-2.xml
UchiStim5s1dhpg20sCa12-3-3-2-2.xml
UchiStim5s25dhpg20sCa12-3-3-2-2.xml
UchiStim5s5dhpg20sCa12-3-3-2-2.xml
                            
<Morphology>

   <!-- spine morphologies: width for sections along the spine -->

    <SpineType id="spineA">
	<Section width="0.2" at="0.0" regionClass="neck"/>
	<Section width="0.2" at="0.2" regionClass="neck"/>
	<Section width="0.2" at="0.3" regionClass="head"/>
	<Section width="0.6" at="0.4" regionClass="head"/>  
	<Section width="0.6" at="0.5" regionClass="PSD"/>
	<Section width="0.2" at="0.6" label="pointA"/>
    </SpineType>

  <SpineType id="spineC">
	<Section width="0.03" at="0.0" regionClass="FAKE"/>
	<Section width="0.02" at="0.03" label="pointD"/>
  </SpineType>
  
  
    <!-- regionClass labels can apply to sections or segments and label regions for applying initial conditaions etc -->


    <!-- lengthDensity means you set the number per micron along the segment -->
    <SpineAllocation id="sa1" spineType="spineA" region="dendrite" lengthDensity="0.8"/>
    <!--SpineAllocation id="sa2" spineType="spineC" region="dendrite" lengthDensity="6.0"/-->
    <SpineAllocation id="sa2" spineType="spineC" region="dendrite" lengthDensity="3.0"/>
    
    <Segment   id="seg1"    region="dendrite">
        <start x="1.0"    y="1.5"   z="0.0"  r="0.5" label="pointB"/>
        <end   x="3.0"    y="1.5"   z="0.0"  r="0.5" label="pointC"/>
    </Segment>


</Morphology>