Gq coupled signaling pathways involved in striatal synaptic plasticity (Kim et al. 2013)

 Download zip file 
Help downloading and running models
Accession:154967
Model of Gq coupled signaling pathways underlying synaptic plasticity in striatal medium spiny projection neurons. Reactions and diffusion are implemented stochastically in a dendrite with one or more diffusionally coupled spines. Simulations demonstrate that theta burst stimulation, which produces LTP, increases the ratio of PKC:2AG as compared to 20 Hz stimulation, which produces LTD.
Reference:
1 . Kim B, Hawes SL, Gillani F, Wallace LJ, Blackwell KT (2013) Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS Comput Biol 9:e1002953 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): mGluR1;
Gene(s):
Transmitter(s):
Simulation Environment: NeuroRD;
Model Concept(s): Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; mGluR1;
/
KimEtAl2013
MorphLong
Robust
readme.txt
discretized-tree.swc
mglu_2ag_reac12mar20desens025.xml
mglu_2ag_reac12mar20desens025Bapta.xml
mglur_2ag_init12mar1lowrGabg.xml *
mglur_2ag_init12mar1lowrGabgBapta10.xml
mglur_morph.xml
mglur_outPIKnewCaM.xml
mglur_stim20hz-10sITI-2xCa30dhpg.xml
mglur_stimTheta2xCa30dhpg.xml
mglurMaster20hz12mar20desens025lowrG.xml
mglurMaster20hz12mar20desens025lowrG-Bapta.xml
mglurMasterTheta12mar20desens025lowrG.xml
NeuroRD2.1.1newtableNP30.jar
sample_output-fast-conc.txt
sample_output-mesh.txt
sample_output-slow-conc.txt
UchiModel12mar20desen025lowrG_100ms0dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms1dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms25dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms5dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_1s0dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s1dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s25dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s5dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s0dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s1dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s25dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s5dhpg20sCa12-3.xml
UchiStim100ms0dhpgCaRate12.xml
UchiStim100ms1dhpg20sCa12.xml
UchiStim100ms25dhpg20sCa12.xml
UchiStim100ms5dhpg20sCa12.xml
UchiStim1s0dhpgCaRate12-3.xml
UchiStim1s1dhpg20sCa12-3.xml
UchiStim1s25dhpg20sCa12-3.xml
UchiStim1s5dhpg20sCa12-3.xml
UchiStim5s0dhpgCaRate12-3-3-2-2.xml
UchiStim5s1dhpg20sCa12-3-3-2-2.xml
UchiStim5s25dhpg20sCa12-3-3-2-2.xml
UchiStim5s5dhpg20sCa12-3-3-2-2.xml
                            
<OutputScheme>
<!--
     Each file will have a set of concentrations in compartments
     sampled according to a specific dt
-->

<!--
    Every Output block must have in its definition one (and only)
    instance of:
     * filename
    And might have one (and only) instance of:
     * region or
     * dt
    If "region" is ommited then the concs for the whole system will be
    saved.
    If "dt" is ommited than the concs will be written at each time step.
    So the "io file" will be dependent on information stated in the
    "morph" (regions) and "model" (dt).
-->

    <OutputSet filename = "fast"  dt="5.0">
      <OutputSpecie name="Dhpg"             />
      <OutputSpecie name="Ca"             /> 
    </OutputSet>
    
   <OutputSet filename = "slow"  dt="50.0">
      <OutputSpecie name="DhpgMgluDesen"             />
      <OutputSpecie name="DhpgMglu"             />
      <OutputSpecie name="GabgDhpgMglu"           />
     <OutputSpecie name="GaGTP"             />
     <OutputSpecie name="Gabg"             />
     <OutputSpecie name="Pip2"             />
     <OutputSpecie name="Plc"            /> 
     <OutputSpecie name="PlcCa"            /> 
     <OutputSpecie name="PlcGaGTP"           /> 
     <OutputSpecie name="PlcCaGaGTP"           /> 
     <OutputSpecie name="PlcCaPip2"        /> 
     <OutputSpecie name="PlcCaGaGTPPip2"    /> 
     <OutputSpecie name="Dag"             /> 
     <OutputSpecie name="Ip3"            /> 
     <OutputSpecie name="Pkc"             /> 
     <OutputSpecie name="PkcCa"           /> 
     <OutputSpecie name="Pkct"            /> 
     <OutputSpecie name="Dgl"             /> 
     <OutputSpecie name="CaDgl"             /> 
     <OutputSpecie name="DagCaDgl"             /> 
     <OutputSpecie name="2ag"            /> 
     <OutputSpecie name="CalbinC"           /> 
     <OutputSpecie name="pmcaCa"          />  
     <OutputSpecie name="ncxCa"          /> 
     <OutputSpecie name="CaMCa4"          /> 
     <OutputSpecie name="CaMCa2C"          /> 
     <OutputSpecie name="CaMCa2N"          /> 
     <OutputSpecie name="DagKdag"             /> 
     <OutputSpecie name="PA"             /> 
     <OutputSpecie name="Ip3degrad"             /> 
     <OutputSpecie name="Ip3degPIk"             /> 
     <OutputSpecie name="PIkinase"             /> 
     <OutputSpecie name="2agDegrad"             /> 
   </OutputSet>
   
   
</OutputScheme>