Gq coupled signaling pathways involved in striatal synaptic plasticity (Kim et al. 2013)

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Accession:154967
Model of Gq coupled signaling pathways underlying synaptic plasticity in striatal medium spiny projection neurons. Reactions and diffusion are implemented stochastically in a dendrite with one or more diffusionally coupled spines. Simulations demonstrate that theta burst stimulation, which produces LTP, increases the ratio of PKC:2AG as compared to 20 Hz stimulation, which produces LTD.
Reference:
1 . Kim B, Hawes SL, Gillani F, Wallace LJ, Blackwell KT (2013) Signaling pathways involved in striatal synaptic plasticity are sensitive to temporal pattern and exhibit spatial specificity. PLoS Comput Biol 9:e1002953 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): mGluR1;
Gene(s):
Transmitter(s):
Simulation Environment: NeuroRD;
Model Concept(s): Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; mGluR1;
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KimEtAl2013
MorphLong
Robust
readme.txt
discretized-tree.swc
mglu_2ag_reac12mar20desens025.xml
mglu_2ag_reac12mar20desens025Bapta.xml
mglur_2ag_init12mar1lowrGabg.xml *
mglur_2ag_init12mar1lowrGabgBapta10.xml
mglur_morph.xml
mglur_outPIKnewCaM.xml
mglur_stim20hz-10sITI-2xCa30dhpg.xml
mglur_stimTheta2xCa30dhpg.xml
mglurMaster20hz12mar20desens025lowrG.xml
mglurMaster20hz12mar20desens025lowrG-Bapta.xml
mglurMasterTheta12mar20desens025lowrG.xml
NeuroRD2.1.1newtableNP30.jar
sample_output-fast-conc.txt
sample_output-mesh.txt
sample_output-slow-conc.txt
UchiModel12mar20desen025lowrG_100ms0dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms1dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms25dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_100ms5dhpg20sCa12.xml
UchiModel12mar20desen025lowrG_1s0dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s1dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s25dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_1s5dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s0dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s1dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s25dhpg20sCa12-3.xml
UchiModel12mar20desen025lowrG_5s5dhpg20sCa12-3.xml
UchiStim100ms0dhpgCaRate12.xml
UchiStim100ms1dhpg20sCa12.xml
UchiStim100ms25dhpg20sCa12.xml
UchiStim100ms5dhpg20sCa12.xml
UchiStim1s0dhpgCaRate12-3.xml
UchiStim1s1dhpg20sCa12-3.xml
UchiStim1s25dhpg20sCa12-3.xml
UchiStim1s5dhpg20sCa12-3.xml
UchiStim5s0dhpgCaRate12-3-3-2-2.xml
UchiStim5s1dhpg20sCa12-3-3-2-2.xml
UchiStim5s25dhpg20sCa12-3-3-2-2.xml
UchiStim5s5dhpg20sCa12-3-3-2-2.xml
                            
<StimulationSet>


    <!-- the injectionSite must match a regionLabel deefined in the morphology  -->
   
 <!-- one dendrite injection, specifying sa2[0:3], with a rate distributed over all the spine (each spine gets total/num spines) 
DHGP has been changed to once per Ca pulse, but 1/4 the value-->

   <!-- *****************TRAIN 1 *** DHPG inject **********-->   
  <InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>               20000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 20066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
  </InjectionStim>

<!--  Ca pulses TRAIN 1 -- 40 Ca pulses -->

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>               20000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 20066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>               20000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 20066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>


<!--------**********DHPG *******TRAIN 2************---------->
  <InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>               35000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 35066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>  
  </InjectionStim>
  
<!--  Ca pulses TRAIN 2 - 80 total Ca pulses -->

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>               35000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 35066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>       
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>               35000          </onset>
        <duration>            3              </duration>
        <rate>               260            </rate>
        <period>              20             </period>
        <end>                 35066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>     
</InjectionStim>


<!--------*********DHPG******TRAIN 3***************---------->
  <InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>               50000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 50066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
  </InjectionStim>
  
<!-----Calcium TRAIN 3-----120 total Ca pulses ------>

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>               50000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 50066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>      
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>               50000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 50066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>   
</InjectionStim>


<!--------**********DHPG******TRAIN 4******************------>
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>               65000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 65066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>     
</InjectionStim>
  
<!---***Ca TRAIN 4 - 160 total pulses -------->

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>               65000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 65066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval> 
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>               65000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 65066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval> 
</InjectionStim>


<!--------*********DHPG******TRAIN 5***************---------->
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>               80000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 80066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>  
</InjectionStim>

<!--------*******Ca TRAIN 5 200 pulses **********------------>


<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>               80000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 80066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>               80000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 80066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>


<!--------**********DHPG******TRAIN 6******************------>
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>               95000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 95066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<!--------**********Calcium******TRAIN 6******* 240 total Ca pulses ***********------>

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>               95000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 95066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>  
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>               95000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 95066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>   
</InjectionStim>

<!--------*********DHPG******TRAIN 7***************---------->
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>              110000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 110066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>


<!--------**********Calcium******TRAIN 7******* 280 total Ca pulses ***********------>

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>              110000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 110066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>              110000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 110066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<!--------*********DHPG******TRAIN 8***************---------->
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>              125000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 125066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<!--------**********Calcium******TRAIN 8******* 320 total Ca pulses ***********------>


<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>              125000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 125066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>      
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>              125000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 125066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>


<!--------*********DHPG******TRAIN 9***************---------->
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>              140000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 140066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>    
</InjectionStim>

<!--------**********Calcium******TRAIN 9******* 360 total Ca pulses ***********------>


<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>              140000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 140066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>       
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>              140000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 140066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>       
</InjectionStim>


<!--------*********DHPG******TRAIN 10***************---------->
<InjectionStim specieID="Dhpg" injectionSite="sa1[0].pointA">
        <onset>              155000          </onset>
        <duration>            5              </duration>
        <rate>                30.0           </rate>
        <period>              20             </period>
        <end>                 155066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>       
</InjectionStim>
<!--------**********Calcium******TRAIN 10******* 320 total Ca pulses ***********------>

<InjectionStim specieID="Ca" injectionSite="sa1[0].pointA">
        <onset>              155000          </onset>
        <duration>            3              </duration>
        <rate>                256            </rate>
        <period>              20             </period>
        <end>                 155066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>     
</InjectionStim>

<InjectionStim specieID="Ca" injectionSite="sa2[0:3].pointD">
        <onset>              155000          </onset>
        <duration>            3              </duration>
        <rate>                260            </rate>
        <period>              20             </period>
        <end>                 155066          </end>
        <numTrains>           10             </numTrains>
        <interTrainInterval>  29             </interTrainInterval>     
</InjectionStim>


</StimulationSet>