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Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
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This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Damodaran S, Evans RC, Blackwell KT (2014) Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum.
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Neostriatum medium spiny direct pathway GABA cell;
Neostriatum medium spiny indirect pathway GABA cell;
Neostriatum fast spiking interneuron;
Detailed Neuronal Models;
Blackwell, Avrama [avrama at gmu.edu];
Damodaran, Sriraman [dsriraman at gmail.com];
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Neostriatum medium spiny direct pathway GABA cell
Neostriatum medium spiny indirect pathway GABA cell
Other models using SPcell.spikes:
Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
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