Information transmission in cerebellar granule cell models (Rossert et al. 2014)

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Accession:156733
" ... In this modeling study we analyse how electrophysiological granule cell properties and spike sampling influence information coded by firing rate modulation, assuming no signal-related, i.e., uncorrelated inhibitory feedback (open-loop mode). A detailed one-compartment granule cell model was excited in simulation by either direct current or mossy-fiber synaptic inputs. Vestibular signals were represented as tonic inputs to the flocculus modulated at frequencies up to 20 Hz (approximate upper frequency limit of vestibular-ocular reflex, VOR). Model outputs were assessed using estimates of both the transfer function, and the fidelity of input-signal reconstruction measured as variance-accounted-for. The detailed granule cell model with realistic mossy-fiber synaptic inputs could transmit infoarmation faithfully and linearly in the frequency range of the vestibular-ocular reflex. ... "
Reference:
1 . Rössert C, Solinas S, D'Angelo E, Dean P, Porrill J (2014) Model cerebellar granule cells can faithfully transmit modulated firing rate signals. Front Cell Neurosci 8:304 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Action Potentials; Markov-type model;
Implementer(s): Solinas, Sergio [solinas at unipv.it]; Roessert, Christian [christian.a at roessert.de];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell;
TITLE Cerebellum Granule Cell Model

COMMENT
        Gaba A leakage
   
	Author: A. Fontana
	Last revised: 18.2.99
ENDCOMMENT
 
NEURON { 
	SUFFIX GRANULE_LKG2 
	NONSPECIFIC_CURRENT il
	RANGE Q10_diff,Q10_channel,gbar_Q10
	RANGE egaba, g , ic, gbar
} 
 
UNITS { 
	(mA) = (milliamp) 
	(mV) = (millivolt) 
} 
 
PARAMETER { 
	v (mV) 
	gbar = 6e-5 (mho/cm2) : Increased of 200% for Jorntell
	egaba = -65 (mV)
	Q10_diff	= 1.5
	celsius (degC)
} 

ASSIGNED { 
	il (mA/cm2) 
	ic (mA/cm2) 
	g (mho/cm2)
	gbar_Q10 (mho/cm2)
}

BREAKPOINT { 
    gbar_Q10 = gbar*(Q10_diff^((celsius-30)/10))
    g = gbar_Q10
    il = g*(v - egaba) 
    ic =il
}