Granule Cells of the Olfactory Bulb (Simoes_De_Souza et al. 2014)

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Accession:156828
Electrical responses of three classes of granule cells of the olfactory bulb to synaptic activation in different dendritic locations. The constructed models were based on morphological detailed compartmental reconstructions of three granule cell classes of the olfactory bulb with active dendrites described by Bhalla and Bower (J. Neurophysiol. 69: 1948-1965, 1993) and dendritic spine distributions described by Woolf et al. (J. Neurosci. 11: 1837-1854, 1991). The computational studies with the model neurons showed that different quantities of spines have to be activated in each dendritic region to induce an action potential, which always was originated in the active terminal dendrites, independently of the location of the stimuli and the morphology of the dendritic tree.
Reference:
1 . Bhalla US, Bower JM (1993) Exploring parameter space in detailed single neuron models: simulations of the mitral and granule cells of the olfactory bulb. J Neurophysiol 69:1948-65 [PubMed]
2 . Woolf TB, Shepherd GM, Greer CA (1991) Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb. J Neurosci 11:1837-54 [PubMed]
3 . Simões-de-Souza FM, Antunes G, Roque AC (2014) Electrical responses of three classes of granule cells of the olfactory bulb to synaptic inputs in different dendritic locations. Front Comput Neurosci 8:128 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Synaptic Integration; Olfaction;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Olfactory bulb main interneuron granule MC GABA cell; Olfactory bulb main interneuron granule TC GABA cell; AMPA; NMDA; 
// Type III granule cell
// Modified from Upinder S. Bhalla, Caltech, May 1991, Aug 91
// fields are ..
// name
// parent
// x,y,z  // coords of endpoint. 
// dia // needed for memb props. All lengths are in microns.
// ch name density 
// ch name density 
// .....
// Control lines start with '*'. Valid control options are 
// *relative 			- relative coords.
// *absolute			- absolute coords.
// *asymmetric			- use asymmetric compartments
// *symmetric			- use symmetric compartments

// #	name	parent		x	y	z	d	ch	dens	ch	dens	.	.	.

*asymmetric
*relative
*cartesian

*set_global	RM	12.0
*set_global	RA	0.5
*set_global	CM	0.01
*set_global	EREST_ACT	-0.065

*memb_factor 2.0


*start_cell /library/notfakespine1
notfakespine1	none		10	0	0	2
neck     	.      		1.9	0	0	0.23 
head	        .      		0.8	0	0	0.8   AMPA_NMDA -1000e-12 Ca_conc -26e10
*makeproto /library/notfakespine1

*start_cell /library/notfakespine2
notfakespine2	none		10	0	0	2
neck		.		-1.9	0	0	0.23 
head		.		-0.8	0	0	0.8   AMPA_NMDA -1000e-12 Ca_conc -26e10
*makeproto /library/notfakespine2


//*add_spines DENDR_DIAM SPINE_DENS SPINE_SUR   
//Adds membrane surface for collapsed spines to all compartments with
// dia <= DENDR_DIAM; units: DENDR_DIAM (um), SPINE_DENS (1/um), SPINE_SUR (um^2).

*add_spines 5 0.0267 3.37

*start_cell

soma		none		0	0	8	6	Na2_rat_smsnn	1611    K_mit_usb      1313    KM_bsg_upi      1334	KA_bsg_yka	12.7	Rm	200e6

*polar

trunk[0]	soma		20	30	20	2	Na2_rat_smsnn	1.7	K_mit_usb	71
trunk[1]	.		20	60	20	2	Na2_rat_smsnn	1.7	K_mit_usb	71
trunk[2]	.		20	90	10	1.5	Na2_rat_smsnn	1.7	K_mit_usb	71
trunk[3]	.		20	100	10	1.5	Na2_rat_smsnn	1.7	K_mit_usb	71

*compt /library/notfakespine1
trunk[4]	.		20	120	20	1.4	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[5]	.		20	130	20	1.4	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[6]	.		20	140	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[7]	.		20	150	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[8]	trunk[7]	40	160	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[9]	.		40	170	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[10]	.		40	140	20	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
trunk[11]	.		20	160	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine1
trunk[12]	.		20	180	10	1.3	Na2_rat_smsnn	1.7	K_mit_usb	71
*compt /library/notfakespine2
periph1[0]	trunk[12]	10	10	20	1.25	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph1[1]	.		10	20	20	1.25	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph1[2]	.		10	20	20	1.25	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph1[3]	.		10	0	20	1.25	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[0]	.		10	5	20	1.2	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph11[1]	.		10	30	10	1.2	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[2]	.		10	20	30	1.18	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph11[3]	.		10	20	30	1.17	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[4]	.		10	10	20	1.16	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph11[5]	.		10	10	40	1.15	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[6]	.		10	30	40	1.14	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph11[7]	.		10	40	10	1.13	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[8]	.		10	50	10	1.12	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph11[9]	.		10	30	20	1.11	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[10]	.		10	20	20	1.10	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph11[11]	.		10	20	30	1.09	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph11[12]	.		10	30	20	1.08	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph12[0]	periph1[3]	10	-90	30	1.2	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph12[1]	.		10	-80	20	1.2	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph12[2]	.		10	-80	10	1.18	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph12[3]	.		10	-70	30	1.16	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph12[4]	.		10	-90	40	1.15	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph12[5]	.		10	-80	40	1.14	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph12[6]	.		10	-70	20	1.13	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph12[7]	.		10	-60	20	1.12	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph12[8]	.		10	-70	50	1.11	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph12[9]	.		10	-80	10	1.10	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph12[10]	.		10	-90	20	1.09	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph2[0]	trunk[12]	10	150	20	1.2	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph2[1]	.		10	160	10	1.2	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph2[2]	.		10	180	10	1.19	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph2[3]	.		10	190	30	1.18	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph2[4]	.		10	160	30	1.17	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph2[5]	.		10	170	20	1.16	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph21[0]	.		10	170	20	1.03	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph21[1]	.		10	160	20	1.02	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph21[2]	.		10	150	30	1.01	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph21[3]	.		10	160	20	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph21[4]	.		10	140	30	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph21[5]	.		10	150	10	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph21[6]	.		10	170	20	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph21[7]	.		10	150	30	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph22[0]	periph2[5]	10	185	20	1.05	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph22[1]	.		10	190	20	1.03	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph22[2]	.		10	200	30	1.02	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph22[3]	.		10	190	20	1.01	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph22[4]	.		10	200	30	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph22[5]	.		10	220	10	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph22[6]	.		10	190	30	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph22[7]	.		10	190	40	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine2
periph22[8]	.		10	200	30	1.0	Na2_rat_smsnn	1355	K_mit_usb	243
*compt /library/notfakespine1
periph22[9]	.		10	210	20	1.0	Na2_rat_smsnn	1355	K_mit_usb	243


*compt /library/compartment
deep0[0]	soma		10	55	150	1.0
deep0[1]	.		10	35	160	0.8
deep0[2]	.		10	45	140	0.8
deep0[3]	.		10	55	140	0.7
deep0[4]	.		10	65	130	0.6
deep0[5]	.		10	45	160	0.5

deep1[0]	soma		10	135	160	1.0
deep1[1]	.		10	125	150	0.8
deep1[2]	.		10	125	140	0.8
deep1[3]	.		10	115	120	0.7
deep1[4]	.		10	125	140	0.6
deep1[5]	.		10	135	160	0.6
deep1[6]	.		10	145	150	0.5
deep1[7]	.		10	155	150	0.5

deep2[0]	soma		10	-35	170	1.0
deep2[1]	.		10	-45	160	0.8
deep2[2]	.		10	-55	140	0.7
deep2[3]	.		10	-45	150	0.6

deep3[0]	soma		10	-125	160	1.0
deep3[1]	.		10	-155	150	0.8
deep3[2]	.		10	-145	140	0.7
deep3[3]	.		10	-135	160	0.6
deep3[4]	.		10	-125	150	0.6