Model of AngII signaling and membrane electrophysiology (Makadia, Anderson, Fey et al., 2015)

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Accession:156830
We developed a novel multiscale model to bridge neuropeptide receptor-activated signaling pathway with membrane electrophysiology. The model studies the effects of Angiotensin II (AngII) on neuronal excitability changes mediated by signaling dynamics and downstream phosphorylation of ion channels. The multiscale model was implemented as a set of ordinary differential equations solved using the ode15s solver in Matlab (Mathworks, USA). The signaling reactions were modeled with either mass-action or Michaelis--Menten kinetics and ion channel electrophysiology was modeled according to the Hodgkin-Huxley formalism. These models were initially validated against their respective data domains independently and were integrated to develop a multiscale model of signaling and electrophysiology.
Reference:
1 . Makadia HK, Anderson WD, Fey D, Sauter T, Schwaber JS, Vadigepalli R (2015) Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology. Biophys J 108:211-23 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Brainstem;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Signaling pathways; Calcium dynamics; Neuromodulation; Multiscale;
Implementer(s): Makadia, Hirenkumar K [hiren.makadia at gmail.com]; Anderson, Warren D [warren.anderson at jefferson.edu]; Fey, Dirk [dirk.fey at ucd.ie]; Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu];
function modelparameters=LoadParameters();

%% Signaling parameters

p_1_1 = 	1;
p_1_2 = 	2;
p_2_1 = 	1;
p_2_2 = 	1.75;
p_3_1 = 	1;
p_3_2 = 	0.5;
p_4_1 = 	1;
p_4_2 = 	0.06;
p_5_1 = 	1;
p_5_2 = 	0.003;
p_6_1 = 	0.014999625;
p_6_2 = 	0.006;
	
p_7_1 = 	0.41482;
p_7_2 = 	45;
p_8_1 = 	80.357;
p_8_2 = 	180;
	
p_9_1 = 	0.096786;
p_9_2 = 	10.5;
p_10_1 = 	18.75;
p_10_2 = 	42.001;
	
p_11_1 = 	6;
p_12_1 = 	0.01;
p_13_1 = 	0.0001;
	
p_14_1 = 	0.0013;
p_14_2 = 	1;
p_15_1 = 	90.6537658442;
p_15_2 = 	2.466;
	
p_16_1 = 	60;
p_16_2 = 	0.01;
	
p_17_1 = 	3;
p_17_2 = 	1;
p_18_1 = 	3600; % 36 for high Ca baseline condition
p_18_2 = 	144;
p_19_1 = 	1;
p_19_2 = 	6;
p_20_1 = 	0.465;
p_20_2 = 	10;
p_21_1 = 	72;
p_21_2 = 	72;
p_22_1 = 	3.6;
p_22_2 = 	10;
p_23_1 = 	0.6;
p_23_2 = 	0.5;
p_24_1 = 	30;
p_24_2 = 	1;
p_25_1 = 	288;
p_26_1 = 	8;
p_27_1 = 	500;
	
p_28_1 = 	4.89E-04;
p_28_2 = 	1;
p_29_1 = 	4.89E-04;
p_29_2 = 	1;
p_30_1 = 	4.89E-04;
p_30_2 = 	1;
p_31_1 = 	4.89E-04;
p_31_2 = 	1;
p_32_1 = 	4.89E-04;
p_32_2 = 	1;
p_33_1 = 	4.89E-04;
p_33_2 = 	1;
p_34_1 = 	4.89E-04;
p_34_2 = 	1;
p_35_1 = 	4.89E-04;
p_35_2 = 	1;
p_36_1 = 	0.11059;
p_36_2 = 	1;
p_37_1 = 	25;
	
p_38_1 = 	1800;
p_38_2 = 	360;
	
p_39_1 = 	50;
p_39_2 = 	0.1;
p_40_1 = 	19.231;
p_40_2 = 	1;
p_41_1 = 	1000.2;
p_41_2 = 	0.1;
p_42_1 = 	50;
p_42_2 = 	5;
	
p_43_1 = 	0.3431978192;
p_43_2 = 	1.4;
p_44_1 = 	0.35;
	
p_45_1 = 	0.003;
p_46_1 = 	0.35;
p_47_1 = 	0.35;
	
p_48_1 = 	0.3431978192;
p_48_2 = 	1.4;
p_49_1 = 	0.3431978192;
p_49_2 = 	1.4;
p_50_1 = 	6;
p_51_1 = 	6;
	
p_52_1 = 	599995.2000384;
p_52_2 = 	2;
p_53_1 = 	924009.46185689;
p_53_2 = 	2;
p_54_1 = 	0.35;
	
p_55_1 = 	7199942.4004608;
p_55_2 = 	24;
p_56_1 = 	11088113.542283;
p_56_2 = 	24;
p_57_1 = 	0.3431978192;
p_57_2 = 	1.4;
p_58_1 = 	0.35;
	
p_59_1 = 	0.3431978192;
p_59_2 = 	1.4;
p_60_1 = 	0.5;
p_61_1 = 	0.5;
	
p_62_1 = 	25;
	
p_63_1 = 	144;
	
p_64_1 = 	0.15;
p_65_1 = 	0.0079998;
p_65_2 = 	8.6348;
p_66_1 = 	0.0006;
p_66_2 = 	0.1;
p_67_1 = 	0.003;
p_68_1 = 	2.5;
p_69_1 = 	10;
p_70_1 = 	75;
p_71_1 = 	160;
	
p_72_1 = 	1;
p_72_2 = 	1.6;
p_73_1 = 	1;
p_73_2 = 	0.2;
p_74_1 = 	75;
p_74_2 = 	25.5;
p_75_1 = 	90.6537658442;
p_75_2 = 	3.0825;
	
p_76_1 = 	0.0133;
p_77_1 = 	1.6667;
	
p_78_1 = 	25.2;
p_78_2 = 	1;
p_79_1 = 	2.52;
p_79_2 = 	1;
	
p_80_1 = 	0.6;
p_80_2 = 	1;
p_81_1 = 	0.006;
p_81_2 = 	0.0001;
	
p_82_1 = 	0.35719;
p_82_2 = 	45.72;
p_83_1 = 	0.11;
p_84_1 = 	117.33;
p_85_1 = 	39.2;
	
p_86_1 = 	35;
p_86_2 = 	0.336;
p_87_1 = 	55;
	
p_88_1 = 	1.035;
p_88_2 = 	157.32;
p_89_1 = 	2;
	
p_90_1 = 	0.00078582;
p_90_2 = 	11.43;
	
p_91_1 = 	0.00207;
p_91_2 = 	39.33;
	
p_92_1 = 	733.3216665208;
p_92_2 = 	469.32;
p_93_1 = 	52.972972973;
p_93_2 = 	156.8;
p_94_1 = 	20;
	
p_95_1 = 	1.9999600008;
p_95_2 = 	8;
p_96_1 = 	1.1;
p_97_1 = 	10.667;
	
p_98_1 = 	11.9570416105;
p_98_2 = 	220;
p_99_1 = 	4.125;
	
p_100_1 = 	4.2666;
p_100_2 = 	1.024;
p_101_1 = 	1.0311468853;
p_101_2 = 	16.5;
p_102_1 = 	4.9997500125;
p_102_2 = 	80;
p_103_1 = 	0.09;
	
p_104_1 = 	0.003;
p_105_1 = 	1;
p_105_2 = 	0.001;
p_106_1 = 	0.013;
p_107_1 = 	10.8839285714;
p_107_2 = 	12.19;%15.2375
p_108_1 = 	10.8839285714;
p_108_2 = 	12.19;
p_109_1 = 	2.7209642857;
p_109_2 = 	3.04748;
p_110_1 = 	1.8333333333;
p_110_2 = 	4.4;
p_111_1 = 	2.9629962944;
p_111_2 = 	42.6669333;
p_112_1 = 	0.0012;
	
p_113_1 = 	1;
p_113_2 = 	0.001;
p_114_1 = 	4.675;
	
p_115_1 = 	0.0060335;
p_115_2 = 	0.070136;
p_116_1 = 	0.256;
	
p_117_1 = 	31.2;
p_117_2 = 	2.496;
p_118_1 = 	0.056;
p_118_2 = 	0.624;
	
p_119_1 = 	0.05;
p_119_2 = 	1;
	
p_120_1 = 	1.5625;
p_120_2 = 	2;%2.5
p_121_1 = 	1;
p_121_2 = 	2;%2.5
p_122_1 = 	0.6666666667;
p_122_2 = 	16;%20
	
p_123_1 = 	0.5;
p_124_1 = 	0.5;
	
p_125_1 = 	4;
	
p_126_1 = 	1.5625;
p_126_2 = 	2;
p_127_1 = 	1;
p_127_2 = 	2;
	
p_128_1 = 	0.5;
p_129_1 = 	0.5;
	
p_130_1 = 	1;
p_130_2 = 	0.001;
p_131_1 = 	0.014999625;
p_131_2 = 	0.0048;
p_132_1 = 	0.5624859379;
p_132_2 = 	0.36;
p_133_1 = 	3.0475;
p_134_1 = 	3.0475;
p_135_1 = 	0.76187;
	
p_136_1 = 	0.001;
p_136_2 = 	1;
p_137_1 = 	179.8076923077;
p_137_2 = 	18.7;
	
p_138_1 = 	0.15;
p_139_1 = 	0.003;
	
p_140_1 = 	53.75;
p_140_2 = 	17.2;
p_141_1 = 	0.013;
p_142_1 = 	1;
p_142_2 = 	0.001;
p_143_1 = 	0.000335;
	
p_144_1 = 	0.001;
p_144_2 = 	1;
p_145_1 = 	0.2321;
	
p_146_1 = 	0.01355;
	
p_147_1 = 	0.26875;
p_147_2 = 	4.3;
	
p_148_1 = 	0.001;
p_148_2 = 	1;
p_149_1 = 	0.0132;
	
p_150_1 = 	1;
p_150_2 = 	45;
p_151_1 = 	1;
p_152_1 = 	1.92;
p_153_1 = 	1.75E-005;
p_154_1 = 	1;
p_154_2 = 	0.001;
p_155_1 = 	0.1746268657;
p_155_2 = 	0.936;
p_156_1 = 	0.034047619;
p_156_2 = 	0.2288;
	
p_157_1 = 	0.001;
p_157_2 = 	1;
p_158_1 = 	29.0125;
p_158_2 = 	0.9284;
	
p_159_1 = 	1;
p_159_2 = 	16;
p_160_1 = 	0.0038;
p_160_2 = 	2.376;
p_161_1 = 	1;
p_161_2 = 	0.001;
p_162_1 = 	1;
p_162_2 = 	19;
p_163_1 = 	2.7216666667;
p_163_2 = 	6.532;
p_164_1 = 	5.1;
	
p_165_1 = 	0.0012;
p_165_2 = 	1.26;
p_166_1 = 	0.0108695652;
p_166_2 = 	0.25;
	
p_167_1 = 	0.001;
p_167_2 = 	1;
p_168_1 = 	220;
p_168_2 = 	0.0528;
	
p_169_1 = 	0.0016666667;
p_169_2 = 	0.05;
	
p_170_1 = 	1923;
p_170_2 = 	10;
	
p_171_1 = 	0.00012;
p_171_2 = 	0.1;
	
p_172_1 = 	1;
p_173_1 = 	50;
	
p_174_1 = 	0.0012;
p_174_2 = 	0.1;
p_175_1 = 	1.2705;
p_176_1 = 	3.5026;
p_177_1 = 	0.6;
p_177_2 = 	0.5;
	
p_178_1 = 	1;
p_179_1 = 	0.1;
	
p_180_1 = 	0.018;
p_180_2 = 	2;
	
p_181_1 = 	2;
p_182_1 = 	0.2;
	
p_183_1 = 	0.6250312516;
p_183_2 = 	12.5;
	
p_184_1 = 	1.6667;
p_185_1 = 	2.5200342725;
p_185_2 = 	50;
	
p_186_1 = 	160.003200064;
p_186_2 = 	800;
	
p_187_1 = 	75;
p_187_2 = 	375;
	
p_188_1 = 	0.234;
p_189_1 = 	0.0572;
	
p_190_1 = 	0.0027;
p_190_2 = 	2.5;
p_191_1 = 	0.6165;
p_192_1 = 	1.633;
	
p_193_1 = 	3.00E-004;
	
p_194_1 = 	1923;
p_194_2 = 	10;

p_195_1 = 25;

p_196_1 = 586.65;

p_197_1 = 196;

p_198_1 = 15.2375;

p_199_1 = 15.2375;

p_200_1 = 3.80935;

p_201_1 = 53.3339333;

p_202_1 = 1.17;

p_203_1 = 0.286;

p_204_1 = 8.165;

p_205_1 = 10;

p_206_1 = 20.625;

p_207_1 = 275;

p_208_1 = 100;

p_209_1 = 5.5;

p_210_1 = 0.45;

p_211_1 = 23.375;

p_212_1 = 1.1605;

p_213_1 = 0.066;

p_214_1 = 0.2;

p_215_1 = 0.04;

p_216_1 = 20.4;

p_217_1 = 1.75;
p_218_1 = 1.75;
p_219_1 = 1.75;
p_220_1 = 1.75;
p_221_1 = 1.75;

p_222_1 = 2.5;
p_223_1 = 30;

p_224_1 = 2.5;
p_225_1 = 2.5;
p_226_1 = 2.5;
p_227_1 = 2.5;
p_228_1 = 2.5;

p_229_1 = 30;
p_230_1 = 0.006;
p_231_1 = 20;


g.na = 3;% Na, g,max
g.kdr = 0.9;% Kdr, g,max
g.ka = 0.15;% Ka, g,max
g.kahp = 0.15; % Kahp, g,max
g.cal = 0.0015; % CaL, g,max
g.leak = 0.01; % gleak, g,max

%phosMK1.max = 1.35;
%phosPKC1.max = 0.5200;

phosMK1.k_p = 1;  % 0 for CaMKII blocking condition
phosPKC1.k_p = 10; % 0 for PKC blocking condition
vmax = 1.2e-1;

%% initializing all params
modelparameters = [
p_1_1
p_1_2
p_2_1
p_2_2
p_3_1
p_3_2
p_4_1
p_4_2
p_5_1
p_5_2
p_6_1
p_6_2
p_7_1
p_7_2
p_8_1
p_8_2
p_9_1
p_9_2
p_10_1
p_10_2
p_11_1
p_12_1
p_13_1
p_14_1
p_14_2
p_15_1
p_15_2
p_16_1
p_16_2
p_17_1
p_17_2
p_18_1
p_18_2
p_19_1
p_19_2
p_20_1
p_20_2
p_21_1
p_21_2
p_22_1
p_22_2
p_23_1
p_23_2
p_24_1
p_24_2
p_25_1
p_26_1
p_27_1
p_28_1
p_28_2
p_29_1
p_29_2
p_30_1
p_30_2
p_31_1
p_31_2
p_32_1
p_32_2
p_33_1
p_33_2
p_34_1
p_34_2
p_35_1
p_35_2
p_36_1
p_36_2
p_37_1
p_38_1
p_38_2
p_39_1
p_39_2
p_40_1
p_40_2
p_41_1
p_41_2
p_42_1
p_42_2
p_43_1
p_43_2
p_44_1
p_45_1
p_46_1
p_47_1
p_48_1
p_48_2
p_49_1
p_49_2
p_50_1
p_51_1
p_52_1
p_52_2
p_53_1
p_53_2
p_54_1
p_55_1
p_55_2
p_56_1
p_56_2
p_57_1
p_57_2
p_58_1
p_59_1
p_59_2
p_60_1
p_61_1
p_62_1
p_63_1
p_64_1
p_65_1
p_65_2
p_66_1
p_66_2
p_67_1
p_68_1
p_69_1
p_70_1
p_71_1
p_72_1
p_72_2
p_73_1
p_73_2
p_74_1
p_74_2
p_75_1
p_75_2
p_76_1
p_77_1
p_78_1
p_78_2
p_79_1
p_79_2
p_80_1
p_80_2
p_81_1
p_81_2
p_82_1
p_82_2
p_83_1
p_84_1
p_85_1
p_86_1
p_86_2
p_87_1
p_88_1
p_88_2
p_89_1
p_90_1
p_90_2
p_91_1
p_91_2
p_92_1
p_92_2
p_93_1
p_93_2
p_94_1
p_95_1
p_95_2
p_96_1
p_97_1
p_98_1
p_98_2
p_99_1
p_100_1
p_100_2
p_101_1
p_101_2
p_102_1
p_102_2
p_103_1
p_104_1
p_105_1
p_105_2
p_106_1
p_107_1
p_107_2
p_108_1
p_108_2
p_109_1
p_109_2
p_110_1
p_110_2
p_111_1
p_111_2
p_112_1
p_113_1
p_113_2
p_114_1
p_115_1
p_115_2
p_116_1
p_117_1
p_117_2
p_118_1
p_118_2
p_119_1
p_119_2
p_120_1
p_120_2
p_121_1
p_121_2
p_122_1
p_122_2
p_123_1
p_124_1
p_125_1
p_126_1
p_126_2
p_127_1
p_127_2
p_128_1
p_129_1
p_130_1
p_130_2
p_131_1
p_131_2
p_132_1
p_132_2
p_133_1
p_134_1
p_135_1
p_136_1
p_136_2
p_137_1
p_137_2
p_138_1
p_139_1
p_140_1
p_140_2
p_141_1
p_142_1
p_142_2
p_143_1
p_144_1
p_144_2
p_145_1
p_146_1
p_147_1
p_147_2
p_148_1
p_148_2
p_149_1
p_150_1
p_150_2
p_151_1
p_152_1
p_153_1
p_154_1
p_154_2
p_155_1
p_155_2
p_156_1
p_156_2
p_157_1
p_157_2
p_158_1
p_158_2
p_159_1
p_159_2
p_160_1
p_160_2
p_161_1
p_161_2
p_162_1
p_162_2
p_163_1
p_163_2
p_164_1
p_165_1
p_165_2
p_166_1
p_166_2
p_167_1
p_167_2
p_168_1
p_168_2
p_169_1
p_169_2
p_170_1
p_170_2
p_171_1
p_171_2
p_172_1
p_173_1
p_174_1
p_174_2
p_175_1
p_176_1
p_177_1
p_177_2
p_178_1
p_179_1
p_180_1
p_180_2
p_181_1
p_182_1
p_183_1
p_183_2
p_184_1
p_185_1
p_185_2
p_186_1
p_186_2
p_187_1
p_187_2
p_188_1
p_189_1
p_190_1
p_190_2
p_191_1
p_192_1
p_193_1
p_194_1
p_194_2
p_195_1
p_196_1
p_197_1
p_198_1
p_199_1
p_200_1
p_201_1
p_202_1
p_203_1
p_204_1
p_205_1
p_206_1
p_207_1
p_208_1
p_209_1
p_210_1
p_211_1
p_212_1
p_213_1
p_214_1
p_215_1
p_216_1
p_217_1
p_218_1
p_219_1
p_220_1
p_221_1
p_222_1
p_223_1
p_224_1
p_225_1
p_226_1
p_227_1
p_228_1
p_229_1
p_230_1
p_231_1
g.na
g.kdr
g.ka
g.kahp
g.cal
g.leak
phosMK1.k_p
phosPKC1.k_p
vmax
];