CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

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Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
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SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
cadiffus.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
ccanl.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
gskch.mod *
h.mod
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod
ichan2.mod
Ih.mod *
kadbru.mod
kadist.mod *
kapbru.mod
kaprox.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nap.mod
Nasoma.mod *
nca.mod *
nmda.mod *
nmdaca.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
apical-trunk-list.hoc
axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
stim_cell.hoc *
vector-distance.hoc
                            
// This function makes a set of lists, each containing the basal sections
// that form a continuous path: starting from the section attached 
// to the trunk and ending at the basal tip section. 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref bl[150],obl[150]

blcount=0
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[16] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[1] bl[blcount].append()
dendrite[2] bl[blcount].append()
dendrite[3] bl[blcount].append()
dendrite[4] bl[blcount].append()
dendrite[5] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[1] bl[blcount].append()
dendrite[2] bl[blcount].append()
dendrite[3] bl[blcount].append()
dendrite[4] bl[blcount].append()
dendrite[6] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[1] bl[blcount].append()
dendrite[2] bl[blcount].append()
dendrite[3] bl[blcount].append()
dendrite[7] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[1] bl[blcount].append()
dendrite[2] bl[blcount].append()
dendrite[8] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[1] bl[blcount].append()
dendrite[2] bl[blcount].append()
dendrite[9] bl[blcount].append()
dendrite[10] bl[blcount].append()
dendrite[11] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[0] bl[blcount].append()
dendrite[1] bl[blcount].append()
dendrite[2] bl[blcount].append()
dendrite[9] bl[blcount].append()
dendrite[10] bl[blcount].append()
dendrite[12] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[13] bl[blcount].append()
dendrite[14] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[54] bl[blcount].append()
dendrite[55] bl[blcount].append()
dendrite[57] bl[blcount].append()
dendrite[13] bl[blcount].append()
dendrite[15] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[15] bl[blcount].append()
dendrite[17] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])


blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[23] bl[blcount].append()
dendrite[24] bl[blcount].append()
dendrite[25] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])


blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[23] bl[blcount].append()
dendrite[24] bl[blcount].append()
dendrite[26] bl[blcount].append()
dendrite[27] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[23] bl[blcount].append()
dendrite[24] bl[blcount].append()
dendrite[26] bl[blcount].append()
dendrite[28] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[23] bl[blcount].append()
dendrite[29] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[37] bl[blcount].append()
dendrite[38] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[37] bl[blcount].append()
dendrite[39] bl[blcount].append()
dendrite[40] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])


blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[37] bl[blcount].append()
dendrite[39] bl[blcount].append()
dendrite[41] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[42] bl[blcount].append()
dendrite[43] bl[blcount].append()
dendrite[44] bl[blcount].append()
dendrite[45] bl[blcount].append()
dendrite[46] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[42] bl[blcount].append()
dendrite[43] bl[blcount].append()
dendrite[44] bl[blcount].append()
dendrite[45] bl[blcount].append()
dendrite[47] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[49] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[36] bl[blcount].append()
dendrite[50] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])


blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[51] bl[blcount].append()
dendrite[52] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[35] bl[blcount].append()
dendrite[51] bl[blcount].append()
dendrite[53] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])


blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[54] bl[blcount].append()
dendrite[56] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[54] bl[blcount].append()
dendrite[55] bl[blcount].append()
dendrite[57] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])

blcount=blcount + 1
bl[blcount]=new SectionList()
dendrite[54] bl[blcount].append()
dendrite[58] bl[blcount].append()
obl[blcount]=new BasalPath(bl[blcount])


print  "basal-paths.hoc executed" //Obidos