CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:157157
This NEURON code implements a microcircuit of CA1 pyramidal neuron and consists of a detailed model of CA1 pyramidal cell and four types of inhibitory interneurons (basket, bistratified, axoaxonic and oriens lacunosum-moleculare cells). Synaptic plasticity during theta cycles at a synapse in a single spine on the stratum radiatum dendrite of the CA1 pyramidal cell is modeled using a phenomenological model of synaptic plasticity (Graupner and Brunel, PNAS 109(20):3991-3996, 2012). The code is adapted from the Poirazi CA1 pyramidal cell (ModelDB accession number 20212) and the Cutsuridis microcircuit model (ModelDB accession number 123815)
Reference:
1 . Saudargiene A, Cobb S, Graham BP (2015) A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus 25:208-18 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Long-term Synaptic Plasticity; STDP;
Implementer(s): Saudargiene, Ausra [ausra.saudargiene at gmail.com];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell;
/
SaudargieneEtAl2015
readme.html
ANsyn.mod *
bgka.mod *
bistableGB_DOWNUP.mod
burststim2.mod *
cad.mod
cadiffus.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
ccanl.mod *
d3.mod *
gabaa.mod *
gabab.mod *
glutamate.mod *
gskch.mod *
h.mod
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod
ichan2.mod
Ih.mod *
kadbru.mod
kadist.mod *
kapbru.mod
kaprox.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nap.mod
Nasoma.mod *
nca.mod *
nmda.mod *
nmdaca.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
apical-non-trunk-list.hoc
apical-tip-list.hoc
apical-tip-list-addendum.hoc
apical-trunk-list.hoc
axoaxonic_cell17S.hoc
axon-sec-list.hoc
BasalPath.hoc
basal-paths.hoc
basal-tree-list.hoc
basket_cell17S.hoc
bistratified_cell13S.hoc
burst_cell.hoc
current-balance.hoc *
main.hoc
map-segments-to-3d.hoc *
mod_func.c
mosinit.hoc
ObliquePath.hoc *
oblique-paths.hoc
olm_cell2.hoc
pattsN100S20P5_single.dat
PC.ses
peri-trunk-list.hoc
pyramidalNeuron.hoc
randomLocation.hoc
ranstream.hoc
screenshot.png
soma-list.hoc
stim_cell.hoc *
vector-distance.hoc
                            
: "Standard" NMDA model
: Dual exponential, with voltage-dependent max conductance
: A fraction of the current is carried by calcium
: BPG 22-8-11

TITLE nmda synapse 

NEURON {
	POINT_PROCESS NMDAca
	NONSPECIFIC_CURRENT i
	USEION ca READ eca WRITE  ica
        RANGE g,a,b,gNMDAmax,tcon,tcoff,enmda, mgconc, eta, gamma
        RANGE fCa,i,ica
}

UNITS {
        (uS) = (microsiemens)
        (nA) = (nanoamp)
        (mV) = (millivolt)
}

PARAMETER {
	fCa = 1.0	: fraction of current is calcium (BPG)
	tcon = 3 (ms)
	tcoff = 150 (ms)
	enmda = 0 	(mV)
	gNMDAmax = 1	(uS)
	mgconc = 1	(mM)	: magnesium concentration
	eta = 0.33	(/mM)
	gamma = 0.06	(/mV)
}

ASSIGNED {
	eca	(mV)
	v 	(mV)
	i	(nA)
	ica	(nA)
	g       (uS)
	factor
}

INITIAL { 
   LOCAL tp
   a=0  
   b=0 
:   factor=tcon*tcoff/(tcoff-tcon)
   tp = (tcon*tcoff)/(tcoff - tcon) * log(tcoff/tcon)
   factor = -exp(-tp/tcon) + exp(-tp/tcoff)
   factor = 1/factor
}

STATE {
      a
      b
}

BREAKPOINT {
	LOCAL s
	SOLVE states METHOD derivimplicit
	s = 1.0/(1+eta*mgconc*exp(-gamma*v))
        g = b-a
	i = (1-fCa)*gNMDAmax*g*s*(v-enmda)
	ica = fCa*gNMDAmax*g*s*(v-enmda)
}

DERIVATIVE states {
	a' = -a/tcon
	b' = -b/tcoff
}

NET_RECEIVE(wgt) {
        LOCAL x
	x=wgt*factor
	state_discontinuity(a,a+x)
	state_discontinuity(b,b+x)
}